grant
BCCMA: Interplay of Novel Mediators of Vascular Aging Pathologies
Organization PORTLAND VA MEDICAL CENTERLocation PORTLAND, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2028
VANIHUS FederalResearch GrantFY2025AD dementiaAD modelAPOEAPP-PS1APP/PS1ASCVDAblationAccelerationAddressAge related pathologiesAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's disease modelAlzheimer's disease patientAlzheimer's disease riskAlzheimer's patientAlzheimers DementiaAmentiaAneurysmAnimal ModelAnimal Models and Related StudiesAortaApo-EApoE proteinApolipoprotein EApoplexyArteriesArteriosclerotic DementiaAtherosclerosisAtherosclerotic Cardiovascular DiseaseAttenuatedAutoregulationBasal Transcription FactorBasal transcription factor genesBiochemicalBioinformaticsBlood VesselsBlood flowBody TissuesBrainBrain Nervous SystemBrain VascularBrain Vascular AccidentBrain Vascular DisordersCalcifiedCardiovascular DiseasesCell Communication and SignalingCell SignalingCerebral StrokeCerebrovascular ApoplexyCerebrovascular CirculationCerebrovascular DiseaseCerebrovascular DisordersCerebrovascular StrokeCerebrovascular systemCerebrumClinicClinicalClinical ManagementClinical TreatmentCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCoronary ArteriosclerosisCoronary Artery DiseaseCoronary Artery DisorderCoronary AtherosclerosisData BasesDatabasesDementiaDietDiseaseDisorderDisturbance in cognitionEncephalonGene TranscriptionGeneral PopulationGeneral PublicGeneral Transcription Factor GeneGeneral Transcription FactorsGenetic TranscriptionGenetic predisposing factorGoalsHealthHigh Fat DietHomeostasisHumanHypertensionImpaired cognitionIn VitroIntracellular Communication and SignalingIntracranial Vascular DiseasesIntracranial Vascular DisordersIschemic StrokeKetosisKnowledgeLeiomyocyteLinkLocalized LesionMediatingMediatorMiceMice MammalsModelingModern ManMolecularMurineMusNutrientO elementO2 elementOrganOutcomeOxygenPathogenesisPathologyPeptidesPeripheral arterial diseasePhenotypePhysiological HomeostasisPrimary Senile Degenerative DementiaProteomicsQOLQuality of lifeRNA ExpressionRegulationReportingResearch ResourcesResourcesRisk-associated variantRoleSerum Response FactorSignal TransductionSignal Transduction SystemsSignalingSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellStrokeSystemic diseaseTherapeutic EffectTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription Factor SRFTranscription factor genesUpregulationVascular DementiaVascular DiseasesVascular DisorderVascular Hypertensive DiseaseVascular Hypertensive DisorderVascular agingVascular calcificationVeteransabnormal brain functionaccelerated agingaccelerated biological ageaccelerated biological agingage accelerationage associatedage associated pathologiesage correlatedage dependentage dependent pathologiesage induced pathologiesage linkedage relatedage specificaged miceaged mouseaging associated pathologiesaging dependent pathologiesaging induced pathologiesaging pathologiesaging related pathologiesalzheimer modelalzheimer riskarterial stiffeningarterial stiffnessartery stiffeningartery stiffnessatheromatosisatherosclerosis riskatherosclerotic coronary diseaseatherosclerotic diseaseatherosclerotic riskatherosclerotic vascular diseaseattenuateattenuatesbiological signal transductionblood flow in brainblood vessel disorderblood vessels in the brainbrain attackbrain blood circulationbrain blood flowbrain blood vesselsbrain dysfunctionbrain impairmentbrain vascular diseasebrain vascular dysfunctionbrain vascular pathologybrain vascular pathophysiologybrain vasculaturec-fos Serum Response Factorcalcificationcardiovascular disordercardiovascular riskcardiovascular risk factorcell typecerebralcerebral angiopathycerebral blood flowcerebral blood vesselcerebral circulationcerebral vascularcerebral vascular accidentcerebral vascular diseasecerebral vascular dysfunctioncerebral vascular pathologycerebral vasculaturecerebral vasculopathycerebro-vascularcerebrocirculationcerebrovascularcerebrovascular abnormalitycerebrovascular accidentcerebrovascular blood flowcerebrovascular contributions to dementiacerebrovascular defectcerebrovascular disease pathologycerebrovascular dysfunctioncerebrovascular pathologycerebrovascular pathophysiologycerebrovascular vesselscerebrovasculaturecerebrovasculopathyclinical interventionclinical therapycognitive dysfunctioncognitive functioncognitive losscoronary arterial diseasedata basedietsdysfunctional brainelderly micegenetic risk factorgenome wide analysisgenome wide studiesgenome-wide analysisgenome-wide identificationhigh blood pressurehuman tissuehyperpiesiahyperpiesishypertensive diseasehypertensive disorderimprovedin vivoinherited factorinsightintracranial vascular dysfunctionmodel of animalmolecular arraymouse modelmultidisciplinarymultiomicsmultiple omicsmurine modelnatural agingnew approachesnormal agingnormative agingnovelnovel approachesnovel strategiesnovel strategyold micepanomicspatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseaseperipheral artery diseaseprimary degenerative dementiaprogramsrisk allelerisk generisk genotyperisk locirisk locusrisk variantscRNA sequencingscRNA-seqsenile dementia of the Alzheimer typesingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestrokedstrokessynergismtranscription factortranscriptomicstreatment strategytrial regimentrial treatmentvascularvascular contributions in dementiavascular contributions to dementiavascular dysfunctionvascular related dementiavasculature agingvasculopathy
Description preview
Abstract
Vascular dementia (VaD) is the second most common cause of dementia, often triggers progressive
cognitive impairment similar to that of Alzheimer’s disease (AD). The current treatment strategies focusing on
local lesions for AD and dementia have not led to satisfactory outcomes. Therefore, comprehensively
understanding of the…
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