grant
BCCMA: Integrating Nutrition and Metabolic Monitors to Mitigate Cardiometabolic Disparities in our Veterans (VA-iMITIGATE): Metabolic Regulation of Vascular Function in Diabetes
Organization PORTLAND VA MEDICAL CENTERLocation PORTLAND, UNITED STATESPosted 1 Oct 2024Deadline 30 Sept 2028
VANIHUS FederalResearch GrantFY2025Active OxygenAddressAdult-Onset Diabetes MellitusAgingArteriesAttenuatedBlood SerumBlood VesselsBone FormationCalcifiedCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCarotid Artery PlaquesCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessChronic DiseaseChronic IllnessClinicClinical ManagementClinical TreatmentCuesD-GlucoseDevelopmentDextroseDiabetes MellitusDiabetic mouseDietary InterventionDisease ProgressionDisparitiesDisparityDoseDrug Metabolic DetoxicationDrug Metabolic DetoxificationDysfunctionEndothelial CellsEndotheliumEnzyme GeneEnzymesFunctional disorderGeneral PopulationGeneral PublicGlucoseH2O2HealthHeart VascularHigh Fat DietHumanHydrogen PeroxideHydroperoxideHyperglycemiaIn VitroInsulin ResistanceIntervention StudiesIntracellular Communication and SignalingKetosis-Resistant Diabetes MellitusKnowledgeLeiomyocyteLinkLipidsMaturity-Onset Diabetes MellitusMediatingMesenchymalMetabolicMetabolic DiseasesMetabolic DisorderMetabolic Drug DetoxicationsMetabolism of Toxic AgentsMiceMice MammalsModern ManModificationMonitorMurineMusNADPH OxidaseNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNutritionNutrition InterventionsNutritional InterventionsO-GlcNAc Transferase geneO-GlcNAc transferaseOsteogenesisOxidantsOxidative StressOxidative Stress InductionOxidizing AgentsOxygen RadicalsPathogenesisPatientsPermeabilityPhenotypePhysiopathologyPlayPro-OxidantsProteinsReactive Oxygen SpeciesRegulationReportingResearch ResourcesResourcesRoleSTZSerumSignal TransductionSignal Transduction SystemsSignalingSlow-Onset Diabetes MellitusSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellStable Diabetes MellitusStreptozocinStreptozotocinSubcellular ProcessT2 DMT2DT2DMTestingThesaurismosisToxic effectToxicitiesType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUnited States Department of Veterans AffairsUnited States Veterans AdministrationUpregulationVascular DiseasesVascular DisorderVascular Smooth MuscleVascular calcificationVeteransVeterans AdministrationVeterans AffairsZanosaradult onset diabetesarterial stiffeningarterial stiffnessartery stiffeningartery stiffnessattenuateattenuatesbiological signal transductionblood glucose regulationblood vessel disorderbone tissue formationcalcificationcardiometaboliccardiometabolismcardiovascular disordercarotid plaquecell dedifferentiationcell typechronic disordercirculatory systemclinical interventionclinical relevanceclinical therapyclinically relevantdetoxificationdevelopmentaldiabetesdiabetes mouse modeldiabeticdiabetic cardiomyopathydiabetic cardiopathydiabetic cardiopathy diseasediabetic cardiopathy disorderdiabetic cardiovascular diseasediabetic cardiovascular disorderdiet interventioneffective therapyeffective treatmentelectron acceptorendothelial dysfunctionglucose controlglucose homeostasisglucose regulationhuman diseasehyperglycemicin vivoinsightinsulin resistantinsulin toleranceintervention researchinterventional researchinterventional studyinterventions researchketo dietketogenic dietketosis resistant diabetesknock-downknockdownmaturity onset diabetesmetabolism disordermultidisciplinarymultiomicsmultiple omicsnew approachesnovelnovel approachesnovel strategiesnovel strategyobese individualsobese peopleobese personobese populationobese subjectsosteogenicpanomicspathophysiologyprogramsscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesynergismtrial regimentrial treatmenttype 1 and type 2 diabetestype 2 DMtype I and type II diabetestype II DMtype two diabetesvascularvascular dysfunctionvasculopathy
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Abstract Vascular calcification, which leads to arterial stiffness and exacerbates cardiovascular complications,
is a prevalent issue among patients with diabetes mellitus. Currently, there is no effective therapy for vascular
calcification. The Veterans Affairs Diabetes Trial has revealed elevated vascular calcification in the Veterans, but…
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