grant
BCCMA: Foundational Research to Act Upon and Resist Conditions Unfavorable to Bone (FRACTURE CURB)
Organization CENTRAL ARKANSAS VETERANS HLTHCARE SYSLocation NORTH LITTLE ROCK, UNITED STATESPosted 1 Apr 2025Deadline 31 Mar 2029
VANIHUS FederalResearch GrantFY2025ABC Transport ProteinABC Transporter ProteinABC TransportersABCA1ABCA1 proteinATP binding cassette transporter 1ATP-Binding Cassette TransportersActive OxygenAddressAdvanced DevelopmentAdvanced Glycation End ProductsAdvanced Glycosylation End ProductsAffectAgingAgonistAmericanAnabolismApproaches to preventionAutoregulationAwardBindingBiological FunctionBiological ProcessBody TissuesBone DiseasesBone FormationBone MatrixBone RegenerationBone ResorptionBone callusBony CallusCYBACYBA geneCallusCartilageCartilaginous TissueCell BodyCell Communication and SignalingCell SignalingCellsCholesterolClinicalClinical ManagementCollaborationsCommunitiesCytochrome b Light ChainCytochrome b(-245), Alpha SubunitCytochrome b(558), Alpha SubunitCytochromes bDNA Molecular BiologyDeteriorationDiabetes MellitusDiagnosisDiseaseDisorderDistressDown-RegulationEarly DiagnosisEnsureEpidemicExhibitsFDA approvedFractureGene ExpressionGene TranscriptionGene variantGeneral PopulationGeneral PublicGenesGenetic TranscriptionGlycosaminoglycansHDLDT1HealthHip FracturesHip Prosthesis ImplantationHistologyHomeostasisHospitalsHuman GeneticsHydrogen OxideInflammationInflammation ProcessIntracellular Communication and SignalingInvestigatorsKO miceKnock-out MiceKnockout MiceLifelong disabilityLigandsLipidsLiver X ReceptorMacrophageMapsMarrowMediatingMiceMice MammalsModelingMolecularMolecular BiologyMolecular InteractionMorbidityMorbidity - disease rateMucopolysaccharidesMulticellular Inflammation ProcessMurineMusMusculoskeletal PainMφNADPH OxidaseNADPH-dependent O2- generating oxidaseNetwork AnalysisNull MouseOntologyOralOsteoclastic Bone LossOsteocytesOsteogenesisOsteoporosisOsteoporosis preventionOutcome MeasureOxidative StressOxygen RadicalsPTH genePTH-PTHrP ReceptorPTH-Related Peptide ReceptorPTH-Related Protein ReceptorPTH1 receptorPTHLP ReceptorPTHrP ReceptorParathyrinParathyroid HormoneParathyroid Hormone ReceptorParathyroid Hormone Receptor 1Parathyroid Hormone Receptor Type IParathyroid Hormone-Like Peptide ReceptorParathyroid Hormone-Related Peptide ReceptorPathway AnalysisPathway interactionsPatientsPermanent disabilityPhosphatidesPhospholipidsPhysiological HomeostasisPopulationPre-Clinical ModelPreclinical ModelsPrevention approachPro-OxidantsProcessPropertyProteinsPublishingRNA ExpressionReactive Oxygen SpeciesReceptor ActivationReceptor SignalingRenal CellResearchResearch PersonnelResearchersResistanceRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSkeletonSourceTechniquesTestingTherapeuticTissuesTranscriptionVeteransWNT Signaling PathwayWNT signalingWalkingWateradvanced glycation endproductadvanced glycosylation endproductallelic variantbiological signal transductionbiosynthesisbonebone cellbone disorderbone fracturebone fragilitybone healthbone lossbone qualitybone repairbone tissue formationcholesterol-efflux regulatory proteindiabetesdiabeticdiabetic patientdisease modeldisorder modelearly detectionfracture riskfragility fracturegenetic variantgenomic varianthip arthroplastyhip joint replacementhip replacementhip replacement arthroplastyhormonal signalshormone signalshydrogen peroxide generating oxidaseimprovedin vitro Modelin vivoinflammatory modulationinhibitorinnovateinnovationinnovativeinsightkidney cellkinase inhibitorloss of functionmeasurable outcomemortalitynanostringnew approachesnon-diabeticnondiabeticnovelnovel approachesnovel strategiesnovel strategyoutcome measurementoxygen generating oxidaseoxygen producing enzymep22 PHOXparathormonepathwaypharmacologicpreventprevent osteoporosispreventingregenerate bonerepairrepairedresearch studyresistantrespiratory burst oxidaserestorationsalt-inducible kinasescRNA sequencingscRNA-seqside effectsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskeletalskeletonssocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstandard of caresuperoxide forming enzymesuperoxide-generating NADPH oxidasetherapeutic agent developmenttherapeutic developmenttherapeutic targettooltreatment effecttreatment strategy
Description preview
To ensure aging Veterans remain active and mobile with as little musculoskeletal pain as possible, new
approaches to the prevention of osteoporosis and promotion of timely bone regeneration following a fracture are
necessary. This collaborative research study brings together a group of VA investigators with diverse
perspectives, insights, models,…
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