grant
Basis and Function of Lateral Assembly of Cadherin Molecules in Adhesive Junctions of Humans and Model Organisms
Organization UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAHLocation SALT LAKE CITY, UNITED STATESPosted 20 Sept 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025ActinsAdherens JunctionAdhering JunctionAdhesive JunctionAdhesivesAffinityAnchoring JunctionAnimalsArchitectureAutoimmune DiseasesBindingBiologic ModelsBiological ModelsBiophysicsBlebBlisterBody TissuesBullaBullous LesionC elegansC. elegansC.elegansCadherinsCaenorhabditis elegansCell BodyCell IsolationCell JunctionsCell SegregationCell SeparationCell Separation TechnologyCellsCellular MatrixCryo-electron MicroscopyCryoelectron MicroscopyCytoskeletal SystemCytoskeletonDNA mutationDataDesmosomesDevelopmentDiseaseDisorderDrosophilaDrosophila genusDysfunctionElectron CryomicroscopyEndotheliumEngineering / ArchitectureEnvironmentFunctional disorderGeneticGenetic ChangeGenetic defectGenetic mutationGenetics-MutagenesisHigher Order Chromatin FoldingHigher Order Chromatin StructureHigher Order StructureHumanIn SituIntercellular JunctionsIntermediate FilamentsLateralLinkLiposomalLiposomesMacula AdherensMechanical StressMembraneMethodsModel SystemModern ManMolecularMolecular InteractionMorphogenesisMutagenesisMutagenesis Molecular BiologyMutationNode of BizzozeroPhysiologyPhysiopathologyPropertyProteinsResistanceResolutionSingle Crystal DiffractionSkinSolidSpecificitySpot DesmosomeStructureSystemTestingTimeTissuesTranslatingValidationVesicationVisualizationWhole OrganismX Ray CrystallographiesX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray/Neutron CrystallographyXray Crystallographyadhesion receptorautoimmune conditionautoimmune disorderautoimmunity diseasebiophysical approachesbiophysical foundationbiophysical methodologybiophysical methodsbiophysical principlesbiophysical sciencesbiophysical techniquescancer progressioncell sortingcostcryo-EMcryoEMcryogenic electron microscopydevelopmentalextracellularfruit flygenome mutationhuman diseaseintracellular skeletonmembermembrane reconstitutionmembrane structuremodel organismmorphogenetic processmouse modelmurine modelneoplasm progressionneoplastic progressionpathophysiologypreventpreventingreconstitutereconstitutionresistantresolutionstumor progressionvalidations
Description preview
PROJECT SUMMARY / ABSTRACT
Adherens junctions, desmosomes and endothelial junctions are fundamental adhesive junctions crucial to animal
physiology. Mutations and autoimmune diseases targeting them cause severe disorders in humans. Adherens
junctions are found in all solid tissues and link actin cytoskeletons of adjacent cells, while desmosomes…
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