grant
Barrett's esophagus early detection project
Organization DIVISION OF CANCER EPIDEMIOLOGY AND GENETICSLocation UNITED STATES
NIHUS FederalResearch GrantFY2025Acid RefluxActive Follow-upBarrett EsophagusBarrett SyndromeBarrett UlcerBiological MarkersBiopsyBiopsy SampleBiopsy SpecimenBloodBlood Reticuloendothelial SystemBlood SampleBlood SerumBlood specimenBody TissuesCardiaClinicColumnar Epithelial-Lined Lower EsophagusColumnar-Lined EsophagusDNA AlterationDNA Sequence AlterationDataData AnalysesData AnalysisDiseaseDisorderDrugsDysplasiaEarly DiagnosisEndocrine Gland SecretionEndoscopesEndoscopyEsophageal RefluxEsophagusGERDGastro-oesophageal RefluxGastroesophageal RefluxGastroesophageal reflux diseaseGene TranscriptionGenetic AlterationGenetic PolymorphismGenetic TranscriptionGerm LinesGoalsHormonesLaboratoriesMedical centerMedicationPatient SelectionPatientsPatternPeriodicalsPharmaceutical PreparationsPilot ProjectsProteomicsQuestionnairesRNA ExpressionRegistriesRisk FactorsSamplingSequence AlterationSerumStudy of serumTestingTherapeutic HormoneTimeTissue SampleTissuesTranscriptionactive followupbio-markersbiologic markerbiomarkerblood-based biomarkerblood-based markercomparator groupcomparison groupdata interpretationdrug/agentdyscrasiaearly detectionendoscopic imagingesophageal intestinal metaplasiafollow upfollow-upfollowed upfollowupgastric cardiagenomic alterationgenotyped patientspatient registryperiodicperiodicalpilot studypolymorphismscreeningscreeningsstomach cardiatissue biomarkers
Description preview
The goal of this project is to identify a practical blood-based biomarker(s) that can be used as a screening test to determine who has Barrett's esophagus (BE) and who does not. Secondary goals of the project are to characterize germ line and tissue biomarkers associated with BE, and compare biomarkers in non-BE patients with and without GERD.…
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