grant
Balancing Iron and Manganese Homeostasis in Hereditary Hemochromatosis
Organization BROWN UNIVERSITYLocation PROVIDENCE, UNITED STATESPosted 13 May 2026Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY2026Alimentary CanalAttenuatedAutoregulationBackBehaviorBileBile JuiceBile fluidBiologyBloodBlood Reticuloendothelial SystemBody TissuesBronze DiabetesCNS Nervous SystemCentral Nervous SystemDCT1DMT1DNA mutationDefectDietDietary IronDigestive TractDiseaseDisorderDivalent Cation Transporter 1DorsumDysfunctionEnterocytesExcretory functionFe absorptionFe deficiencyFe elementFunctional disorderGI TractGastrointestinal TractGastrointestinal tract structureGenetic ChangeGenetic defectGenetic mutationGoalsHFE2HFE2 geneHFE2AHJVHealthHemochromatosisHepatic CellsHepatic Parenchymal CellHepatobiliaryHepatocyteHepatotoxic effectHepatotoxicityHepc peptideHereditaryHereditary hemochromatosisHomeostasisHuman FigureHuman bodyImpairmentInheritedIntestinalIntestinesIronKnowledgeLiver CellsLiver ToxicityMalnutritionManganeseMediatingMembrane Protein GeneMembrane Protein TrafficMembrane ProteinsMembrane TrafficMembrane-Associated ProteinsMetalsMiceMice MammalsMitochondriaMn elementMolecularMurineMusMutationNRAMP2NeuraxisNutrientNutritional DeficiencyOrganPathway interactionsPatientsPhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyPlayProteinsRGMCReceptor SignalingReportingRoleRouteSLC11A2SLC11A2 geneSecondary toSeverity of illnessSurface ProteinsTestingTissuesToxic effect on liver cellsUndernutritionUpregulationWeaningWorkabsorptionalimentary tractattenuateattenuatesbowelcell typedietarydietary Fedietary deficiencydietsdigestive canaldisease phenotypedisease severitydivalent metal transporter-1excretionferroportinferroportin1 proteingenome mutationhaemojuvelinhemochromatosis type 2 (juvenile)hemojuvelinhepatic toxicityhepatoxicityhepcidininhibitoriron absorptioniron deficiencyiron storage disordermalnourishedmetal transporting protein 1mitochondrialmouse modelmurine modelnatural resistance-associated-macrophage protein 2nutrition deficiencynutrition deficiency disordernutritional deficiency disorderpathophysiologypathwaypreventpreventingrare conditionrare syndromerepulsive guidance molecule csocial rolesolute carrier family 11- (proton-coupled divalent metal ion transporters), member 2solute carrier family 40 (iron-regulated transporter), member 1toxic metal
Description preview
PROJECT SUMMARY: “Balancing Iron and Manganese Homeostasis in Hereditary Hemochromatosis”
Iron (Fe) and manganese (Mn) are essential for health yet toxic in excess. Fe is regulated largely by dietary
absorption, while Mn is regulated largely by hepatobiliary excretion. Our understanding of Fe homeostasis has
benefited greatly from studies of…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click