Bacterial antibiotic resistance: structure, mechanism and inhibition of ABC transporters responsible for drug efflux and cell wall biogenesis.

Bacterial diseases impose a terrible burden of suffering and death throughout the world but for the past 70 years antibiotics have shielded us from the worst. However, we now face serious peril as the development of antibiotic resistance may, in the words of recent Chief Medical Officer Professor Dame Sally Davies, "kill us before climate…