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Bacteria and Host in TB Transmission

Organization RUTGERS BIOMEDICAL AND HEALTH SCIENCESLocation Newark, UNITED STATESPosted 10 Apr 2020Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY2025AICDAAICDA proteinAID geneAID proteinAIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAerosolsAffectAllelesAllelomorphsApoptosisApoptosis PathwayAreaAutophagocytosisBacteriaBiochemicalBrazilCDA2 proteinCell IsolationCell SegregationCell SeparationCell Separation TechnologyCharacteristicsClassificationCollaborationsCoughingDNA mutationDataDiseaseDisorderDrugsEicosanoidsEnabling FactorsEnvironmentEventExposure toFundingGWA studyGWASGeneralized GrowthGenesGeneticGenetic ChangeGenetic defectGenetic mutationGrowthHIVHIV InfectionsHTLV-III InfectionsHTLV-III-LAV InfectionsHealth BenefitHost FactorHost Factor ProteinHouseholdHumanHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsImmuneImmune MarkersImmune responseImmune systemImmunesImmunochemical ImmunologicImmunologicImmunologic MarkersImmunologicalImmunologicallyImmunologicsIn VitroIndividualInfectionInfectious Diseases / LaboratoryInfectious Diseases ResearchInnate Immune ResponseInnate ImmunityIntegration Host FactorsInternationalInterventionLAV-HTLV-IIILymphadenopathy-Associated VirusM tbM tuberculosisM tuberculosis infectionM. tbM. tb infectionM. tuberculosisM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMacrophageMeasuresMedicationMetallopeptidasesMetalloproteasesMetalloproteinasesMiceMice MammalsMinorMinorityModern ManMurineMusMutationMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionMφNative ImmunityNatural ImmunityNon-Specific ImmunityNonspecific ImmunityPathologicPatientsPersonsPharmaceutical PreparationsPhenotypePopulationPredispositionProgrammed Cell DeathProspective, cohort studyPublic HealthResearchRetrospective cohortRoleSamplingScientistSiteSputumStressSusceptibilitySystemSystematicsT cell responseTB infectionTestingTissue GrowthTransmissionTuberculosisUgandaVaccinesVirus-HIVactivation-induced cytidine deaminaseactivation-induced deaminaseadaptive immune responseadaptive immunityaerosolizedautophagycell sortingcommunity spreadcommunity transmissioncommunity-level spreadcommunity-level transmissioncytokinedeep sequencingdevelop a vaccinedevelop vaccinesdevelopment of a vaccinediscover genesdisseminated TBdisseminated tuberculosisdrug developmentdrug/agententire genomefull genomefunctional genomicsgene discoverygenome mutationgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studyhost responseimmune system responseimmune-based biomarkersimmunological biomarkersimmunological markersimmunopathologyimmunoresponseimprovedindexinginfection due to Mycobacterium tuberculosisinnovateinnovationinnovativeinsightlipidomicsmetabolism measurementmetabolomicsmetabonomicsmtbnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynew vaccinesnext generation therapeuticsnext generation vaccinesnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapynovel vaccinesontogenypermissivenesspreventpreventingresponsesample collectionsegregationsocial rolespecimen collectionstudy characteristicstransmission processtuberculosis infectiontuberculous spondyloarthropathyvaccine developmentwhole genomewhole genome association analysiswhole genome association study

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ABSTRACT
Halting tuberculosis (TB) transmission will be most efficiently achieved by focusing control efforts on sites
of high transmission and by developing new drugs and vaccines that target bacterial transmission. We
hypothesize that household TB transmission is dramatically under-estimated because mixed infections are
common and secondary…

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