grant
B cells in the regulation of lung granulomatous inflammation in TB
Organization RUTGERS BIOMEDICAL AND HEALTH SCIENCESLocation Newark, UNITED STATESPosted 13 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025AffectAlabamaAnimalsAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntibodiesAntigen PresentationAntigen-Presenting CellsAntitubercular AgentsB blood cellsB cellB cellsB-Cell DeficiencyB-Cell SubsetsB-CellsB-Lymphocyte SubsetsB-LymphocytesB-cellBacillusBody TissuesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCSIFCSIF-10Cell AggregationCell BodyCell Communication and SignalingCell ComponentsCell FunctionCell PhysiologyCell ProcessCell SignalingCell StructureCellsCellular FunctionCellular PhysiologyCellular ProcessCellular StructuresChronicCollaborationsCollectionCommunicationCytokine Synthesis Inhibitory FactorDataDendritic CellsDevelopmentDisease OutcomeElementsExhibitsFosteringGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGeneralized GrowthGerminal CenterGoalsGranulomaGranulomatousGranulomatous LesionGrowthHumanIFNIL-10IL10IL10AImmuneImmune responseImmunesImmunityImmunofluorescenceImmunofluorescence ImmunologicImmunosuppressionImmunosuppression EffectImmunosuppressive EffectInfectionInfiltrationInflammationInflammatoryInterferonsInterleukin 10 PrecursorInterleukin-10InterventionIntervention StrategiesIntracellular Communication and SignalingKnock-outKnockoutKnowledgeLesionLungLung InflammationLung ParenchymaLung Respiratory SystemLung TBLung TissueLung TuberculosisLung damageM tbM tuberculosisM tuberculosis antigenM tuberculosis infectionM. tbM. tb infectionM. tuberculosisM. tuberculosis antigenM. tuberculosis infectionM.tb antigenM.tb infectionM.tuberculosis infectionMHC ReceptorMTB infectionMacrophageMajor Histocompatibility Complex ReceptorMediatingMiceMice MammalsModelingModern ManMouse StrainsMtb antigenMurineMusMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis antigensMycobacterium tuberculosis infectionMφNatureNecrosisNecroticPathologicPathologyPathway interactionsPhenotypePlayPneumonitisProcessProductionProliferatingPublic HealthPulmonary InflammationPulmonary PathologyPulmonary TBPulmonary TuberculosisReactionRegulationReporter GenesRoleSamplingSignal TransductionSignal Transduction SystemsSignalingStructure of germinal center of lymph nodeStructure of parenchyma of lungSubcellular ProcessT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell immune therapyT cell immunotherapyT cell responseT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-Cell Antigen ReceptorsT-Cell ProliferationT-Cell ReceptorT-CellsT-LymphocyteT-cell therapeuticsT-cell transfer therapyT4 CellsT4 LymphocytesTB diagnosisTB immunityTB infectionTechnologyTestingTissue GrowthTissuesTranscript Expression AnalysesTranscript Expression AnalysisTransgenic MiceTransgenic OrganismsTransmissionTreesTuberculosisTuberculosis diagnosisTuberculostatic AgentsUniversitiesVaccinesVeiled CellsWild Type Mouseaccessory celladoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyanalyze gene expressionanti-TBanti-tuberculosisantiTBbiological signal transductioncurative interventioncurative therapeuticcurative therapycurative treatmentscytokinedepositorydevelopmentaldiagnosed with TBdiagnosed with Tuberculosisdisseminated TBdisseminated tuberculosisexperiencegene expression analysisgene expression assayhost responsehumoral immunity deficiencyimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunity against M. tuberculosisimmunity against Mtbimmunity against Mycobacterium tuberculosisimmunity against TBimmunity against tuberculosisimmunity in tuberculosisimmunity to TBimmunity to tuberculosisimmunopathologyimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseinfection due to Mycobacterium tuberculosislung developmentlung functionlung injurylung pathologymouse modelmtbmurine modelnecrotic tissueontogenypathwaypulmonary damagepulmonary functionpulmonary injurypulmonary tissue damagepulmonary tissue injuryrepositoryrespiratoryresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicstherapeutic T-cell platformthymus derived lymphocytetissue necrosistranscriptional profilingtransgenictransmission processtuberculosis immunitytuberculosis infectiontuberculous spondyloarthropathywildtype mouse
Description preview
A hallmark of the host response to Mycobacterium tuberculosis (Mtb) is the development of the inflammatory granuloma, which plays an important role in controlling Mtb while also capable of inducing tissue-damaging lung pathology in chronic tuberculosis (TB), causing necrosis and cavitation. Cavitary lesions, when in communication with the…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click