grant
B Cells in Preeclampsia: Long-term Effects on Offspring
Organization UNIVERSITY OF MISSISSIPPI MED CTRLocation JACKSON, UNITED STATESPosted 11 Apr 2025Deadline 10 Apr 2028
NIHUS FederalResearch GrantFY20260-11 years old21+ years oldASDAddressAdoptive TransferAdultAdult ChildrenAdult DaughtersAdult HumanAdult OffspringAdult SonsAffectAgeAmentiaAngIIAngiotensin AT1 ReceptorAngiotensin IIAngiotensin II Type 1 ReceptorAnimalsAntigenic DeterminantsApoplexyAthymic RatsAttenuatedAutismAutistic DisorderAutoantibodiesAutoregulationB blood cellsB cellB cellsB-Cell ActivationB-CellsB-LymphocytesB-cellBP reductionBindingBinding DeterminantsBirth WeightBlood ClottingBlood PressureBlood coagulationBp35Brain VascularBrain Vascular AccidentBrain Vascular DisordersCD20CardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCell BodyCell secretionCellsCells Placenta-TissueCellular SecretionCerebral StrokeCerebrovascular ApoplexyCerebrovascular CirculationCerebrovascular DiseaseCerebrovascular DisordersCerebrovascular StrokeCerebrumChildChild YouthChildren (0-21)ChronicClinicalCognition DisordersCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCommon Rat StrainsCytotoxic cellDataDementiaDevelopmentDiseaseDisorderDisturbance in cognitionDysfunctionEPH GestosisEarly Infantile AutismEpitopesExhibitsFemaleFetal Growth RestrictionFetal Growth RetardationFetusFrequenciesFunctional disorderFutureGeneralized GrowthGestationGestational HypertensionGrowthHealthHeart VascularHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHomeostasisHypertensionHypertension induced by pregnancyIUGRImmuneImmune Cell ActivationImmunesImpaired cognitionImpairmentIncidenceInducer CellsInducer T-LymphocytesInfantile AutismInflammationIntracranial Vascular DiseasesIntracranial Vascular DisordersIntrauterine Growth RetardationIschemiaK lymphocyteKanner's SyndromeLeu-16LinkLong-Term EffectsMS4A1MS4A1 geneMS4A2MeasuresMedical centerMemory B CellMemory B-LymphocyteMetabolic DiseasesMetabolic DisorderMississippiModelingMolecular InteractionMorbidityMothersNK CellsNatural Killer CellsNervous System DiseasesNervous System DisorderNeurologic DisordersNeurological DisordersNormal PlacentomaNude RatsOrganOutcomeOxidative StressPatient TransferPeptidesPerinatalPeripartumPhysiological HomeostasisPhysiopathologyPlacentaPlacenta Embryonic TissuePlacentomePost-partum WomenPostpartum PeriodPostpartum WomenPre-Clinical ModelPre-EclampsiaPreclinical ModelsPreeclampsiaPregnancyPregnancy Associated HypertensionPregnancy ComplicationsPregnancy ToxemiasPremature BirthPrematurely deliveringPreterm BirthProcessProteinuria-Edema-Hypertension GestosisRatRats MammalsRattusReceptor ProteinReceptor, Angiotensin, Type 1RiskRoleSafetySeizuresStrokeSyndromeTestingThesaurismosisTissue GrowthUniversitiesVascular Hypertensive DiseaseVascular Hypertensive DisorderWomanactivated B cellsadoptive B cell therapyadoptive B cell transferadulthoodagesangiotensin II type I receptorattenuateattenuatesautism spectral disorderautism spectrum disorderautistic spectrum disorderautoimmune antibodyautoreactive antibodyblood flow in brainblood pressure reductionbrain attackbrain blood circulationbrain blood flowbrain vascular diseasebrain vascular dysfunctioncardiovascular disease riskcardiovascular disordercardiovascular disorder riskcardiovascular riskcardiovascular risk factorcerebralcerebral blood flowcerebral circulationcerebral vascularcerebral vascular accidentcerebral vascular diseasecerebral vascular dysfunctioncerebro-vascularcerebrocirculationcerebrovascularcerebrovascular accidentcerebrovascular blood flowcerebrovascular dysfunctioncirculatory systemcognitive diseasecognitive disordercognitive dysfunctioncognitive functioncognitive losscognitive syndromecomplications during pregnancydevelopmentaldisease riskdisorder riskendothelial dysfunctionfetalhigh blood pressurehyperpiesiahyperpiesishypertension during pregnancyhypertension in pregnancyhypertensive diseasehypertensive disorderhypertensive pregnancyimmune activationimpaired fetal growthimprovedintra-uterine growth restrictionintra-uterine growth retardationintracranial vascular dysfunctionintrauterine growth restrictionkidslater in lifelater lifelower BPlower blood pressurelowers blood pressuremalemanage symptommaternal outcomemetabolism disordermortalitymother outcomeneuro-vascularneurological diseaseneurovascularnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetoffspringontogenypathophysiologypathophysiology of pre-eclampsiapathophysiology of preeclampsiaplacental transferpost-partumpostnatalpre-eclampticpregnancy characterized by hypertensionpregnancy hypertensionpregnancy toxemia/hypertensionpregnancy-related complicationspregnancy-related hypertensionpregnantpremature childbirthpremature deliveryprenatal growth disorderpreterm deliverypreventpreventingprogramsreceptorreduce BPreduce blood pressurereduction in BPreduction in blood pressureself reactive antibodysocial rolestandard of carestrokedstrokessymptom managementvascular constrictionvasoconstrictionyoungster♀♂
Description preview
Preeclampsia (PE), new-onset hypertension during pregnancy with multi-organ dysfunction, is associated with
chronic immune activation and is the leading cause of morbidity and mortality for the mother and fetus. Delivery
of the baby is the current treatment for PE. Today’s therapies focus on managing symptoms instead of preventing
the occurrence.…
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