grant
Axonal and synaptic transformations of melanopsin retinal ganglion cell output
Organization HARVARD MEDICAL SCHOOLLocation BOSTON, UNITED STATESPosted 1 Mar 2026Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2025Action PotentialsAnatomic SitesAnatomic structuresAnatomyAnimalsAreaAutomobile DrivingAxonAxon TerminalsBehaviorBehavioralBiophysical ProcessBiophysicsBrainBrain Nervous SystemBrain regionCell BodyCell Communication and SignalingCell NucleusCell SignalingCellsCircadian RhythmsCranial Nerve IIDataDendritesDisparateDistalElectrophysiologyElectrophysiology (science)EncephalonEndowmentEnvironmentExperimental GeneticsEye diseasesFluorescenceG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGPCRGlutamatesHealthHourIlluminationImageIntracellular Communication and SignalingKnowledgeL-GlutamateLeadLengthLightLight Signal TransductionLightingMammaliaMammalsMeasuresMediatingMethodsMiceMice MammalsMoodsMurineMusNerve CellsNerve Impulse TransmissionNerve TransmissionNerve Transmitter SubstancesNerve UnitNeural CellNeural TransmissionNeurocyteNeuronal TransmissionNeuronsNeurophysiology / ElectrophysiologyNeurotransmittersNucleusNyctohemeral RhythmOptic DiskOptic NerveOptic Nerve HeadOptic PapillaOpticsOutputPACAPPb elementPerceptionPerforationPeripheralPharmacologyPhasePhotoradiationPhotoreceptor CellPhotoreceptorsPhotosensitive CellPhotosensitiveness due to sunPhotosensitivityPhototransductionPhysiologicPhysiologicalPhysiologyPlayPopulationPopulation HeterogeneityPositionPositioning AttributePreparationPresynaptic Nerve EndingsPresynaptic TerminalsProcessPropertyPupilPupil light reflexRetinaRetinal Ganglion CellsRoleSecond Cranial NerveSightSignal TransductionSignal Transduction SystemsSignalingStimulusSurfaceSynapsesSynapticSynaptic BoutonsSynaptic TerminalsSynaptic TransmissionTechniquesTectum MesencephaliTestingTransmissionTravelTwenty-Four Hour RhythmVisionVisualVisual PerceptionVisual ReceptorVisual Transductionawakeaxon signalingaxon-glial signalingaxonal signalingbiological signal transductionbiophysical characteristicsbiophysical characterizationbiophysical foundationbiophysical measurementbiophysical mechanismbiophysical parametersbiophysical principlesbiophysical propertiesbiophysical sciencescell typecircadiancircadian clockcircadian pacemakercircadian processcircadian regulationcircadian rhythmicitydaily biorhythmdesensitizationdesigndesigningdiverse populationsdrivingelectrical propertyelectrophysiologicalexperimentexperimental researchexperimental studyexperimentseye disorderglia signalingglial signalingglutamatergicheavy metal Pbheavy metal leadheterogeneous populationimagingin vivolight intensitymelanopsinmesencephalic tectummidbrain tectummillimetermood regulationnerve signalingneural cell bodyneural signalingneuronalneuronal cell bodyneuronal signalingneurotransmissionocular diseaseocular disorderophthalmopathyopticaloptical discpituitary adenylate cyclase activating peptidepituitary adenylate cyclase activating polypeptidepopulation diversitypostsynapticpreparationspupillary light reflexpupillary reflexreceptive fieldresponseretinal ganglionsleep controlsleep regulationsleep/wake regulationsocial rolesomaspatial and temporalspatial temporalspatiotemporalsun sensitivitysuprachiasmatic nucleussynapsetectaltectumtectum mesencephalicumtectum structuretooltransmission processvisual functionvisual informationvisual phototransductionvoltage
Description preview
PROJECT SUMMARY/ABSTRACT
Animals rely on visual information to interact with their environment. In contrast to visual perception, other
visual functions benefit from a temporally and spatially blurred version of the surroundings – one that is
sensitive to overall illumination (irradiance) instead of image detail. In mammals, these functions rely…
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