grant
Assessment of DCAF15 role in Acute Myeloid Leukemia
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Apr 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAML - Acute Myeloid LeukemiaAPF-1ATP-Dependent Proteolysis Factor 1AcetylationAcetyltransferaseAcuteAcute Myeloblastic LeukemiaAcute Myelocytic LeukemiaAcute Myelogenous LeukemiaAffinityAllelesAllelomorphsAntioncogene Protein p53ApoptosisApoptosis PathwayApplications GrantsArchitectureBAM geneBAM proteinBamacanBindingBinding ProteinsBiochemicalBiologicalBiological FunctionBiological ProcessBlood DiseasesBone Marrow GraftingBone Marrow TransplantBone Marrow TransplantationBortezomibCSPG6CSPG6 geneCancersCell BodyCell FunctionCell Growth in NumberCell MultiplicationCell PhysiologyCell ProcessCell ProliferationCellsCellular FunctionCellular PhysiologyCellular ProcessCellular ProliferationCellular Tumor Antigen P53ChemicalsChondroitin Sulfate Proteoglycan 6ChromatinChromatin LoopChromatin Loop DomainsClinicalComplexCyclicityDNADNA AlterationDNA DamageDNA InjuryDNA LoopDNA ReplicationDNA Sequence AlterationDNA SynthesisDNA biosynthesisDNA mutationDNA replication forkDataDeacetylaseDeacetylationDefectDeoxyribonucleic AcidDependenceDevelopmentDrugsE3 LigaseE3 Ubiquitin LigaseEngineeringEngineering / ArchitectureEventFrequenciesGene ExpressionGenesGeneticGenetic AlterationGenetic ChangeGenetic defectGenetic mutationGenomeGenomicsGrant ProposalsHCAP geneHCAP proteinHDAC8HDAC8 geneHMG-20Hematologic CancerHematologic DiseasesHematologic MalignanciesHematologic NeoplasmsHematological DiseaseHematological DisorderHematological MalignanciesHematological NeoplasmsHematological TumorHematopoiesisHematopoietic CancerHematopoietic Cellular Control MechanismsHigh Mobility Protein 20Histone Deacetylase 8HumanIMiD3 cpdImpairmentInterventionInvestigationKineticsLigand Binding ProteinLigand Binding Protein GeneLigandsLinkMalignant Hematologic NeoplasmMalignant NeoplasmsMalignant TumorMarrow TransplantationMediatingMedicationMetabolic Protein DegradationMiceMice MammalsModern ManMolecularMolecular InteractionMurineMusMutationMyelogenousMyeloidOncogenicOncoprotein p53OutcomeP53PathogenesisPathologicPathway interactionsPatientsPeriodicityPharmaceutical PreparationsPhosphoprotein P53Phosphoprotein pp53PlayPrevalenceProcessPrognosisProgrammed Cell DeathProliferatingProtacProteasome InhibitorProtein BindingProtein TP53Protein TurnoverProteinsProteolysis targeting chimericRecurrenceRecurrentRecyclingRegulationRegulatory ProteinRegulatory Protein DegradationResearchRhythmicityRoleSMC3Sequence AlterationSeriesShapesSignal PathwaySister ChromatidStructural Maintenance Of Chromosomes 3Subcellular ProcessSurvival RateTP53TP53 geneTRP53TechniquesTherapeuticTherapeutic InterventionToxic effectToxicitiesTumor Protein p53Tumor Protein p53 GeneUbiquitinUbiquitin Protein LigaseUbiquitin-Protein Ligase ComplexesUbiquitin-Protein Ligase E3acute granulocytic leukemiaacute granulocytic leukemia cellacute myeloblastic leukemia cellacute myelocytic leukemia cellacute myelogenous leukemia cellacute myeloid leukemiaacute myeloid leukemia cellacute nonlymphocytic leukemia cellbiologicblood cell formationblood disorderbound proteincohesincohesionconditional knock-outconditional knockoutdesigndesigningdevelopmentaldrug/agentexperimentexperimental researchexperimental studyexperimentsgene locusgenetic locusgenetic regulatory proteingenome mutationgenomic alterationgenomic locationgenomic locusin vivoindividualized therapeuticinnovateinnovationinnovativeintervention therapylenalidomideleukemiamalignancymemberneoplasm/cancernew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyp53 Antigenp53 Genesp53 Tumor Suppressorpathwaypersonalized therapeuticprotein degradationprotein p53proteolysis targeting chimaeraproteolysis targeting chimerarecruitregulatory gene productreplication forkreplication stressresponsesmall moleculesmall molecule therapeuticssocial rolesuccesstherapeutic targetthree dimensionalubiquitin-protein ligase
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Project Summary
Acute Myeloid Leukemia (AML) represents a highly aggressive hematologic malignancy characterized by a
multitude of genetic alterations and an exceptionally poor prognosis. Genomic analyses of AML patients have
unveiled recurrent mutations in the cohesin complex, with a prevalence ranging from 5.9% to 13.0%. The
clinical success of…
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