grant
Assessing the role of SP140 in enhanced resistance to Cryptococcus neoformans
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 15 Aug 2024Deadline 14 Aug 2028
NIHUS FederalResearch GrantFY2025AIDS VirusAIDS/HIVAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAlveolusAntigensBloodBlood Reticuloendothelial SystemBody TissuesBreedingBronchial AlveolusC neoformansC. neoformansC3HeB/FeJ MouseC57BL/6 MouseCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCNS DiseasesCNS disorderCNS infectionCell BodyCell Communication and SignalingCell SignalingCellsCentral Nervous System DiseasesCentral Nervous System DisordersCentral Nervous System InfectionsCentral Nervous System Infectious DiseaseCentral Nervous System Infectious DisorderCessation of lifeCharacteristicsClinicalClinical TrialsContainmentCryptococcal MeningitisCryptococcosisCryptococcusCryptococcus neoformansCryptococcus neoformans infectionDataDeathDeath RateDevelopmentDiseaseDisease OutcomeDisease ProgressionDisorderDrugsEnvironmentExpression SignatureGene Expression ProfileGene TranscriptionGenesGenetic TranscriptionGranulomaGranulomatous LesionHIVHIV/AIDSHaplotypesHistologicHistologicallyHumanHuman Immunodeficiency VirusesIFNIMiDImmuneImmune Modulation TherapyImmune modulatory therapeuticImmune responseImmunesImmunocompetentImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunomodulationImmunosuppressed HostImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImpairmentIndividualInfectionInfection ControlInflammatoryInhalationInhalingInnate Immune ResponseInterferonsIntracellular Communication and SignalingLAV-HTLV-IIILifeLung GranulomaLymphadenopathy-Associated VirusM tbM tuberculosisM tuberculosis infectionM. tbM. tb infectionM. tuberculosisM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMacrophageMapsMeasuresMediatingMedicationMethodsMiceMice MammalsMicroscopyModelingModern ManMurineMusMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionMφNecrosisNecroticNervous System InjuriesNervous System TraumaNervous System damageNeurological DamageNeurological InjuryNeurological traumaPathway interactionsPatientsPharmaceutical PreparationsPhenotypePopulationPredispositionProductionRNA ExpressionReproduction sporesResearchResistanceRoleSignal TransductionSignal Transduction SystemsSignalingSporesStructureSusceptibilityT-Cell DepletionT-cell depletion therapyT-lymphocyte depletion therapyT4 CellsT4 LymphocytesTB infectionTestingTherapeutic FungicidesTimeTissuesTorulaTorulosisTranscriptionTuberculosisVirus-HIVWorld Health Organizationadaptive immune responseaggressive therapyaggressive treatmentanti-fungalanti-fungal agentsanti-fungal drugantiretroviral therapyantiretroviral treatmentbiological signal transductionc neoformans infectionc. neoformans infectioncell typeclinical translationclinically translatableco-infectioncoinfectioncytokinedevelopmentaldisseminated TBdisseminated tuberculosisdrug/agentfungal pathogenfungi pathogenfungicidalfungicidegene expression patterngene expression signatureglobal healthhost responsehuman diseasehuman modelhypoimmunityimmune competentimmune deficiencyimmune modulating agentsimmune modulating drugimmune modulating therapeuticsimmune modulationimmune modulatory agentsimmune modulatory drugsimmune modulatory therapiesimmune modulatory treatmentimmune reconstitutionimmune regulationimmune regulation therapyimmune regulation treatmentimmune regulatory therapyimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmune-modulation treatmentimmunodeficiencyimmunogenimmunologic reactivity controlimmunomodulating agentsimmunomodulating drugsimmunomodulation therapyimmunomodulation treatmentimmunomodulator agentimmunomodulator drugimmunomodulator medicationimmunomodulator prodrugimmunomodulator therapeuticimmunomodulator therapiesimmunomodulator treatmentimmunomodulator-based therapiesimmunomodulatoryimmunomodulatory agentsimmunomodulatory biologicsimmunomodulatory drugsimmunomodulatory therapeuticsimmunomodulatory therapiesimmunomodulatory treatmentimmunoregulationimmunoregulatoryimmunoregulatory therapyimmunoregulatory treatmentimmunoresponseimmunosuppressed patientimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedin vivo Modelinfection due to Mycobacterium tuberculosisinsightlatent infectionmodel of humanmortalitymortality ratemortality ratiomouse modelmtbmurine modelneurotraumanew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetpathogenpathogenic funguspathwaypreventpreventingpulmonarypulmonary granulomarecruitresistantresponsesocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstandard of caretherapeutic agent developmenttherapeutic developmenttherapeutic immunomodulationtherapeutic immunoregulationtime usetimelinetooltranscriptional profiletranscriptional signaturetuberculosis infectiontuberculous spondyloarthropathy
Description preview
Project Abstract
The HIV/AIDS associated fungal pathogen Cryptococcus neoformans (Cn) is responsible for 20% of
global HIV-related mortality and has been designated on the World Health Organization Critical Fungal Patho-
gens list. Cn is the causative agent of cryptococcal meningitis (CM), a severe infection of the central nervous
system that…
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