grant
Assessing the mechanisms directing cell fate in the dorsal spinal cord
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 1 May 2022Deadline 30 Apr 2027
NIHUS FederalResearch GrantFY2026ATRAAddressAdoptedAfter CareAfter-TreatmentAftercareBMP type I receptorBMP4BMPR-IBasal Transcription FactorBasal transcription factor genesBone Morphogenetic Protein GeneBone Morphogenetic ProteinsCell BodyCell Communication and SignalingCell SignalingCell modelCellsCellular modelChIP SequencingChIP-seqChIPseqChicken ModelChicken animal modelChickensComplexConnector NeuronDataDevelopmentDevelopmental BiologyDiseaseDisorderDorsalDrug ModulationDrug ScreeningES Cell LineES cell differentiationESC differentiationEmbryonic Stem Cell LineEmotional well beingEnvironmentFamilyFamily memberFeels wellGallus domesticusGallus gallusGallus gallus domesticusGametesGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenetic TranscriptionGerm CellsGerm-Line CellsGrowth AgentsGrowth FactorGrowth SubstancesIn VitroIndividualInjuryIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronIntracellular Communication and SignalingIntracellular Second MessengerItchingLigandsLightLogicMediatingMedicalMedulla SpinalisMiceMice MammalsModalityModelingMouse ES CellMouse ESCMouse Embryonic ProgenitorMouse Embryonic Stem CellsMurineMusNatureNeural Stem CellNociceptionNormal mental conditionNormal mental stateNormal psycheOutcomePainPainfulPalsyParalysedPathway interactionsPatientsPatternPeripheralPhotoradiationPlegiaPluripotent Stem CellsPopulationProcessProductionProliferatingProprioceptionProtein FamilyProteins Growth FactorsProtocolProtocols documentationPruritic DisorderPruritisPruritusPsychological Well BeingRNA ExpressionReactionReceptor ProteinReproductive CellsResearchResolutionRetinoic AcidRoleSHHSHH geneSecond Messenger SystemsSecond MessengersSense of well-beingSensorySeriesSex CellSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSonic HedgehogSpecific qualifier valueSpecifiedSpinalSpinal CordSpinal cord damageSubgroupSystemTouchTouch sensationTrans Vitamin A AcidTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranslatingTretinoinTretinoinumVitamin A AcidWNT Signaling PathwayWNT signalingWell in selfall-trans-Retinoic Acidall-trans-Vitamin A acidanalyze gene expressionbiological signal transductionbone morphogenetic protein receptor type Ibone morphogenic proteincell typechromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingdesigndesigningdevelopmentaldifferentiation factorsdifferentiation in embryonic stem cellsdifferentiation protocoldrug detectiondrug testingembryonic precursor differentiationembryonic stem cell differentiationemotional wellbeingemotional wellnessgene expression analysisgene expression assayglobal gene expressionglobal transcription profilein vivoinitial cellinjuriesitch sensationknock-downknockdownmESCmembermental well-beingmental wellbeingmental wellnessmorphogenic factorsmorphogensmotor controlmouse modelmurine ES cellsmurine ESCmurine embryonic progenitormurine embryonic stem cellmurine modelnerve stem cellneuralneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurogenic progenitorsneurogenic stem cellneuron progenitorsneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitornociceptiveparalysisparalyticpathwaypluripotent progenitorpost treatmentprogenitorprogenitor and neural stem cellsprogenitor cell fateprogenitor cell modelprogenitor fateprogenitor modelpsychological wellbeingpsychological wellnessreceptorrepairrepairedresolutionsresponseself wellnesssense of wellbeingsexual cellsignal transduction second messengerssmall molecular inhibitorsmall molecule inhibitorsocial rolesomatosensorystem and progenitor cell fatestem and progenitor cell modelstem cell based modelstem cell derived modelstem cell fatestem cell modeltactile sensationtrans-Retinoic Acidtranscription factortranscriptional profilingtranscriptometranscriptomics
Description preview
Project Summary
The somatosensory system permits us to perceive and react to the environment through modalities that
include touch, nociception, thermosensation and proprioception. Somatosensory information is received
peripherally and then relayed centrally by different populations of dorsal interneurons (dIs; dI1-dI6) in the spinal
cord. Our…
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