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Assessing TGF Beta1-Mediated ECM Remodeling in Metastatic Oral Squamous Cell Carcinoma
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 1 Dec 2022Deadline 30 Nov 2025 ⚠️
NIHUS FederalResearch GrantFY2025AffectAtomic Force MicroscopyBone-Derived Transforming Growth FactorBreast CancerCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCRISPRCRISPR/Cas systemCancersCarcinoma CellCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell LineCell SignalingCell-Extracellular MatrixCell-to-Cell InteractionCellLineCellsCheckpoint inhibitorClustered Regularly Interspaced Short Palindromic RepeatsCollagenCollagen GeneCollagen Type IConsensusDNA mutationDataDependenceDepositDepositionDiseaseDisorderDistant CancerDistant MetastasisDropsECMEpidermoid CarcinomaEsophagusExclusionExperimental TherapiesExtracellular MatrixFailureFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryForce MicroscopyGeneral Prognostic FactorGenesGeneticGenetic ChangeGenetic defectGenetic mutationGlycoprotein GP-2GoalsHumanImmuneImmune RegulatorsImmune checkpoint inhibitorImmune systemImmunesImmunocompetentImmunomodulatorsIn VitroInfiltrationIntegrin BindingIntegrinsIntegrins Extracellular MatrixIntracellular Communication and SignalingInvadedInvestigational TherapiesInvestigational TreatmentsKRAS(G12D)KRASG12DKeratinKnock-outKnockoutLYT3LaboratoriesLamininLungLung Respiratory SystemLymphatic cellLymphocyteLymphocyte CountLymphocyte NumberLymphocyticLymphocytic InfiltrateMalignant Breast NeoplasmMalignant CellMalignant Epithelial CellMalignant NeoplasmsMalignant Oral Cavity NeoplasmMalignant Oral Cavity TumorMalignant Oral NeoplasmMalignant TumorMeasuresMediatingMetastasisMetastasis to the LungMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic Neoplasm to the LungMetastatic Squamous Cell CarcinomaMetastatic TumorMetastatic Tumor to the LungMiceMice MammalsMilk Growth FactorModelingModern ManMotilityMouth CancerMurineMusMutationNSCLCNSCLC - Non-Small Cell Lung CancerNeoplasm MetastasisNon-Small Cell Lung CancerNon-Small-Cell Lung CarcinomaNon-metastaticNonmetastaticOral CancerOral Cavity Squamous Cell CarcinomaOral squamous cell carcinomaOutcomePatient CarePatient Care DeliveryPatientsPlanocellular CarcinomaPlatelet Transforming Growth FactorPrimary CarePrimary NeoplasmPrimary TumorProductionProgenitor CellsPrognostic FactorPrognostic MarkerPrognostic/Survival FactorProteinsRNA SeqRNA sequencingRNAseqRegulationRiskSamplingScanning Force MicroscopySecondary NeoplasmSecondary TumorSignal TransductionSignal Transduction SystemsSignalingSquamous CarcinomaSquamous Cell EpitheliomaSquamous cell carcinomaStem Cell likeStrains Cell LinesSurvival RateT8 CellsT8 LymphocytesTGF BTGF-Beta 1TGF-Beta1TGF-betaTGF-βTGFBTGFB1TGFB1 geneTGFbetaTGFβTestingTotal Lymphocyte CountTransforming Growth Factor Beta 1Transforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTransplantationTumor-Infiltrating LymphocytesType 1 Collagenanti-tumor immune responsebiological signal transductioncancer cellcancer metastasiscancer microenvironmentcancer progenitorcancer progenitor cellscancer riskcancer stem cellcancer stem like cellcancer typecare for patientscare of patientscaring for patientscheck point immunotherapycheck point inhibitor therapycheck point inhibitory therapycheck point therapycheckpoint immunotherapycheckpoint inhibitor therapycheckpoint inhibitory therapycheckpoint therapycrosslinkcultured cell lineexperimental therapeutic agentsexperimental therapeuticsflow cytophotometrygenome mutationhigh riskimmune check point inhibitorimmune check point therapyimmune checkpoint therapyimmune competentimmune modulatorsimmunomodulatory moleculesimmunoregulatorimmunoregulatory moleculesimprovedin vivoinhibitorinsightintegrin boundlung metastasislymph cellmalignancymalignant breast tumormalignant mouth neoplasmmalignant mouth tumormalignant progenitormalignant stem cellmetastasize to the lungmigrationmouse modelmouth SCCmouth squamous cell carcinomamurine modelneoplasm/canceroncogenic progenitoroncogenic stem cellsoral cavity SCCoral cavity canceroral squamous canceroral squamous carcinomaprogenitor capacityprogenitor cell expansionprogenitor cell likeprogenitor expansionprogenitor like cancer cellprogenitor-likeprognostic biomarkerprognostic indicatorpulmonary metastasisresponsestandard of carestem and progenitor cell expansionstem cell characteristicsstem cell expansionstem cellsstem like cancer cellstem-likestemnesssuccesstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targettraffickingtraittranscriptome sequencingtranscriptomic sequencingtransforming growth factor beta1transplanttumortumor cell metastasistumor microenvironment
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Description preview
Abstract
Oral squamous cell carcinoma (OSCC) patients have a dismal survival rate due to distant metastases that
escape primary care. Transforming growth factor beta (TGFβ) is a well-known driver of metastasis, modulator of
immune cell activity, and regulator of extracellular matrix (ECM) genes. In breast cancer, a stiff ECM is generally…
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