grant
Assessing spatial frequency domain imaging as an objective quantification of longitudinal skin changes in scleroderma
Organization BOSTON UNIVERSITY MEDICAL CAMPUSLocation BOSTON, UNITED STATESPosted 2 Apr 2025Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2025AddressAreaAutoimmuneAutoimmune DiseasesBody TissuesClinicalClinical TrialsClinical Trials DesignCognitive DiscriminationCollagenCollagen FiberConnective Tissue DiseasesConnective Tissue DisorderCutaneous DisorderDermalDermatologic biopsyDermatosesDiffuse SclerodermaDisability assessment scaleDisability indexDisability scaleDisability status scaleDiscriminationDiseaseDisease ManagementDisease MarkerDisease ProgressionDisorderDisorder ManagementDropsyEdemaFDA approvedFibroblastsForearmFutilityFutureGoalsHistologicHistologicallyHistologyHydropsImageIndividualInter-Observer VariabilityInter-Observer VariationInterobserver VariabilityInterobserver VariationsLabelLightMeasurementMeasuresMethodsModelingMonitorObservation researchObservation studyObservational StudyObservational researchOpticsOutcomeOutcome MeasurePainPainfulPatient Outcomes AssessmentsPatient Reported MeasuresPatient Reported OutcomesPatientsPenetrationPerformancePhasePhotoradiationPhysiciansPilot ProjectsProcessProgressive SclerodermaPropertyQOLQuality of lifeQuestionnairesResearchSYS-TXSclerodermaSeveritiesSeverity of illnessSkinSkin DiseasesSkin Diseases and ManifestationsSpatial Frequency Domain ImagingStandardizationSumSystemSystemic SclerodermaSystemic SclerosisSystemic TherapyTechniquesTherapeutic StudiesTherapy ResearchThickThicknessTimeTissuesTreatment EfficacyTrichrome stainValidationVariantVariationabsorptionassess effectivenessautoimmune conditionautoimmune disorderautoimmunity diseasecostcutaneous biopsycutaneous diseasecutaneous fibrosisdermal diseasedermal disorderdermal fibrosisdermatosclerosisdesigndesigningdetermine effectivenessdiffuse systemic sclerosisdisease severitydrug developmenteffectiveness assessmenteffectiveness evaluationevaluate effectivenessexamine effectivenessfibrotic skinhealth assessmentimagingimprovedindexingindividual patientintervention efficacymeasurable outcomemortalitynovelopticaloutcome measurementpilot studyprogressive systemic sclerosisprospectivepublic health relevanceresponseresponse to therapyresponse to treatmentshared decision makingskin biopsyskin disorderskin fibrosisstemsuccesstherapeutic efficacytherapeutic responsetherapy efficacytherapy responsetooltreatment responsetreatment responsivenessultrasoundvalidations
Description preview
PROJECT SUMMARY/ABSTRACT
Systemic sclerosis (SSc) is an autoimmune connective tissue disease, with a 10-year mortality of 40%, the
highest of all autoimmune diseases. Painful, itchy skin tightening is an early feature, and can have a major impact
on quality of life and daily living. Clinically, quantification of skin fibrosis in SSc is performed…
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