grant
Assessing Risk for Poor Outcomes in Antiphospholipid Syndrome
Organization HOSPITAL FOR SPECIAL SURGERYLocation New York, UNITED STATESPosted 1 Jul 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY202521+ years oldAddressAdultAdult HumanAgeAlgorithmsAmericanAnti-Phospholipid Antibody SyndromeAnti-phospholipid SyndromeAnticoagulationAntiphospholipid AntibodiesArteriesAssayAutoantibodiesBioassayBioinformaticsBiological AssayBiological MarkersBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood VesselsCardiac infarctionClassificationClinicalCodeCoding SystemCohort StudiesComplement ActivationConcurrent StudiesDataData AnalysesData AnalysisData BasesData SetDatabasesDevelopmentDiagnosisElectronic Health RecordEnvironmentEpidemiologyEuropeanEventFamilial antiphospholipid syndromeFundingFutureGestationGrantHealth SciencesHospitalsHughes syndromeICD-10ICD-10-CMImmunologyInstitutionInterferon Type IInternationalInternational Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10)InvestigatorsIschemic StrokeK23 AwardK23 MechanismK23 ProgramKnowledgeLaboratoriesLeadershipLifeMachine LearningMarrow NeutrophilMedicineMentored Patient-Oriented Research Career Development AwardMentored Patient-Oriented Research Career Development Award (K23)MentorsMentorshipMethodologyMethodsMicrovascular DysfunctionModelingModificationMorbidityMorbidity - disease rateMyocardial InfarctMyocardial InfarctionNatural Language ProcessingNeutrophilic GranulocyteNeutrophilic LeukocyteObesityOperative ProceduresOperative Surgical ProceduresOutcomePatientsPhenotypePhlebothrombosisPhosphatidesPhospholipidsPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPositionPositioning AttributePredicting RiskPregnancyProductivityPublishingPulmonary EmbolismRandom AllocationRandom SelectionRegistriesResearchResearch PersonnelResearch TrainingResearchersRheumatologyRiskRisk AssessmentRisk FactorsRoleSamplingServicesSiteSmokingSpecial HospitalsStatistical MethodsSurgicalSurgical InterventionsSurgical ProcedureSystematicsTechniquesTestingTrainingVenous ThrombosisWorkadiposityadulthoodagesautoimmune antibodyautoreactive antibodybio-markersbiologic markerbiomarkerbiomed informaticsbiomedical informaticscardiac infarctcareer developmentclinical careclinical phenotypeclinical predictorsclinical riskcohortcollegecollegiatecomplement pathway regulationcomputable phenotypescoronary attackcoronary infarctcoronary infarctioncorpulencedata basedata interpretationdesigndesigningdevelopmentalelectronic health care recordelectronic health medical recordelectronic health plan recordelectronic health registryelectronic medical health recordelectronic structureepidemiologicepidemiologicalextracellularforecasting riskheart attackheart infarctheart infarctionhigh dimensionalityimprovedimproved outcomemachine based learningmalleable riskmicrovascular complicationsmicrovascular diseasemodifiable riskmortalitymultidisciplinarymultiorgan damagenatural language understandingneutrophilnew markernovelnovel biomarkernovel markerpatient registrypatient stratificationpersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentphenotyping algorithmpopulation basedpopulation healthpredict clinical outcomepredict riskpredict riskspredicted riskpredicted riskspredicting riskspredictive riskpredicts riskprofessorprospectiverisk predictionrisk predictionsrisk stratificationscreeningscreeningsself reactive antibodyskillssmall vessel diseasesocial rolesocio-demographic groupssocio-demographicssociodemographic groupsociodemographicsstatistic methodsstratified patientstratify riskstructured datasurgerysystemic autoimmune diseasesystemic autoimmune disorderthrombotictreatment strategyunstructured dataunsupervised learningunsupervised machine learningvascularvenous thromboembolism
Description preview
PROJECT SUMMARY/ABSTRACT
Background: This proposal is designed for Medha Barbhaiya, MD, MPH to grow towards becoming an
independent investigator focused on developing and validating a novel method to identify antiphospholipid
syndrome (APS) in large cohorts, evaluating its utility in identifying poor APS outcomes in multi-center EHR
cohorts, and…
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