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Assessing direction selectivity map development in the retina

Organization UNIVERSITY OF CALIFORNIA BERKELEYLocation BERKELEY, UNITED STATESPosted 1 Feb 2022Deadline 19 Dec 2025 ⚠️
NIHUS FederalResearch GrantFY20252-photon21+ years oldAD dementiaASDAdultAdult HumanAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAnimalsAnteriorAutismAutistic DisorderCalciumCell BodyCell Communication and SignalingCell SignalingCellsCerebral cortexComplexCranial Nerve IIDataDegenerative Neurologic DisordersDevelopmentDiseaseDisorderEarly Infantile AutismEyeEyeballGeneticGoalsImageInfantile AutismInferiorIntracellular Communication and SignalingInvestigationKO miceKanner's SyndromeKnock-outKnock-out MiceKnockoutKnockout MiceKnowledgeLabelLocationMapsMediatingMesencephalonMiceMice MammalsMid-brainMidbrainMidbrain structureModelingMotionMovementMurineMusNasalNasal Passages NoseNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurodevelopmental DisorderNeurologic Degenerative ConditionsNeurological Development DisorderNicotinic Acetylcholine ReceptorsNicotinic ReceptorsNoseNull MouseOptic NervePathologyPatternPeripheralPharmacologyPopulationPrimary Senile Degenerative DementiaProcessProtirelin ReceptorsRespiratory System, Nose, Nasal PassagesRetinaRoleSecond Cranial NerveSensorySignal TransductionSignal Transduction SystemsSignalingSourceSpatial DistributionSpecificitySurfaceSynapsesSynapticTRH ReceptorsTechnologyTestingThalamic structureThalamusThyroliberin ReceptorsThyrotropin-Releasing Hormone ReceptorsVariantVariationVisualadulthoodautism spectral disorderautism spectrum disorderautistic spectrum disorderbiological signal transductionbody movementcholinergicdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigndesigningdevelopmentalexperiencegangliocyteganglion cellimagingimaging detectionimaging-based detectionimaging-based disease detectioninformation processinginsightinterestmouse modelmurine modelneural circuitneural circuitryneurocircuitryneurodegenerative illnessneurodevelopmental diseaseoptic flowpharmacologicpostnatalpostsynapticprimary degenerative dementiapromoterpromotorresponsesenile dementia of the Alzheimer typesocial rolestarburst amacrinestarburst amacrine cellstemsynapsesynapse inhibitionsynaptic circuitsynaptic circuitrysynaptic inhibitionthalamictooltwo-photonvisual informationvisual stimulusvoltage clamp

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Description preview

Project Summary
Visual information is processed through a set of neural circuits that organize into functional
maps distributed throughout the thalamus, midbrain, and cerebral cortex. However, little is known
about how circuits develop and organize in the retina, where this information processing begins. The
goal of this proposal is to determine…

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