grant
Arthropod saliva in vector-borne disease transmission: Functional analysis of novel domains in salivary secretions
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025Activated Blood Coagulation Factor XActivated Factor XAdhesion MoleculeAffectAnimalsAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAnticoagulant AgentsAnticoagulant DrugsAnticoagulantsArthropodaArthropodsAutoprothrombin CAzurophil Granule Protein 7BindingBiochemicalBiologyBiteBlack FliesBlackfliesBloodBlood ClottingBlood ProteinsBlood Reticuloendothelial SystemBlood coagulationBrazilC-ANCAC-ANCA AntigenCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCatalytic CoreCatalytic DomainCatalytic RegionCatalytic SiteCatalytic SubunitCathepsin GCell Adhesion Molecule GeneCell Adhesion MoleculesCell Surface ReceptorsChemotactic CytokinesCoagulation Factor XaComplementComplement ProteinsCulicidaeDrugsEntomologyEnzyme GeneEnzymesEsteroproteasesFactor XaFamilyFemaleFliesGranulocyte ElastaseHealthHeart VascularHemostatic AgentsHemostaticsHomologous Chemotactic CytokinesHumanImmuneImmune responseImmunesImmunityImmunosuppressantsImmunosuppressive AgentsImmunosuppressive drugImmunosuppressive treatmentIn VitroInfectionInflammationInflammatoryInflammatory ResponseIntercrinesIxodidaLaboratoriesLatin AmericanLectinLeukocyte ElastaseLeukocyte Proteinase 3Lysosomal ElastaseMediatingMedicationMedicineMiningModelingModern ManMolecularMolecular InteractionMosquitoesMyeloblastinN-proteinase 4NP-4NP4(3)NamesNational Institutes of HealthNeutrophil ElastaseNeutrophil Proteinase 4Neutrophil Serine ProteinaseOcular OnchocerciasisOnchocerca volvulusPMN ElastasePR-3ParasitesPathway interactionsPeptidasesPeptide HydrolasesPharmaceutical PreparationsPhlebotominaePhysiologyPolymorphonuclear Leukocyte ElastaseProcessProduce salivaPropertyProtease GeneProteasesProteinase 3ProteinasesProteolytic EnzymesResearchRiver BlindnessRoleSIS cytokinesSalivaSaliva productionSalivarySalivary Gland ProteinsSalivary GlandsSalivary ProteinsSalivary excretionSalivationSerine EndopeptidasesSerine ProteaseSerine Protein HydrolasesSerine ProteinasesSimuliidaeSimuliumSimulium genusTherapeuticThrombokinaseThrombosisTicksTranslational ResearchTranslational ScienceTransmissionTripcellimTrypsinTryptaseUnited States National Institutes of HealthVector-borne diseaseVector-borne infectious diseaseVector-transmitted diseaseVector-transmitted infectious diseaseVenezuelaVirusWegener AutoantigenWegener Granulomatosis AutoantigenZoonosesZoonoticZoonotic Infectionalpha-chymotrypsinblocking factorblood mealblood thinnercell adhesion proteinchemoattractant cytokinechemokinechymotrypsin Achymotrypsin A alphacirculatory systemcommunicable disease transmissioncomplement pathwaycomplementationcytokinedisease transmissiondrug/agentfeedingflyhost responseimmune suppressive agentimmune suppressorimmune system responseimmunoresponseimmunosuppressive substanceimmunosuppressorin vivoinfectious disease transmissioninhibitorinsightlung tryptasemast cell protease IImast cell tryptasenamenamednamingneutrophil proteinase 3novelp29p29bpathogenpathwayprothrombasesaliva secretionsalivary productionsalivary secretionsandflyskin tryptasesocial rolethrombopoiesis inhibitorthrombotic diseasethrombotic disordertranslation researchtranslational investigationtransmission processvectorvector-borne illnessvectorborne diseasevectorborne illnessvectorborne infectious disease♀
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The main accomplishments of the Molecular Entomology Section is:
1. Identification of a novel anti-hemostatic activities isolated from the “river blindness” vector, Simulium guianense.
Black flies, known also as “buffalo gnats”, are very small, robust flies that are annoying biting pests of humans and wildlife, and can also transmit parasites…
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