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Arterivirus receptors: rules of engagement for cross-species infection
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 11 Dec 2023Deadline 31 Oct 2025 ⚠️
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoVAirAnimalsArteriviridaeArterivirusArterivirus InfectionsAssayBindingBioassayBiologicalBiological AssayBiologyBiomedical ResearchBlind SpotsBypassCOVID crisisCOVID epidemicCOVID pandemicCOVID-19COVID-19 crisisCOVID-19 epidemicCOVID-19 eraCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 pandemicCOVID-19 periodCOVID-19 public health crisisCOVID-19 virusCOVID-19 yearsCOVID19 virusCRISPRCRISPR/Cas systemCV-19Cell BodyCell surfaceCellsCellular MembraneChromosome MappingClustered Regularly Interspaced Short Palindromic RepeatsCoV-2CoV2CollectionCommunitiesComplexCoronaviridaeCoronavirusCoronavirus Infectious Disease 2019DNA mutationDevelopmentDiagnosticDiseaseDisease OutbreaksDisorderDistantDomestic AnimalsDomestic HorseEndosomesEquineEquine SpeciesEquus caballusEquus przewalskiiEventFamilyFamily suidaeFc ReceptorFcRnFcRn neonatal transfer proteinFood SupplyFoundationsFutureGene LocalizationGene MappingGene Mapping GeneticsGene ProteinsGenesGeneticGenetic ChangeGenetic DiversityGenetic VariationGenetic defectGenetic mutationHealthHorsesHost FactorHost Factor ProteinHumanInfectionIntegration Host FactorsInterventionInvestmentsKnock-outKnockoutKnowledgeLeannessLifeLife CycleLife Cycle StagesLinkage MappingMammaliaMammalsMapsMediatingMiceMice MammalsModern ManMolecularMolecular InteractionMonkey Hemorrhagic Disease VirusMonkeysMurineMusMutationOrthocoronavirinaeOrthologOrthologous GeneOutbreaksPathogenesisPersonal SatisfactionPigsPositionPositioning AttributePredispositionPrimatesPrimates MammalsPropertyProtein Gene ProductsRNA VirusesReceptor ProteinReceptosomesResearchResearch ResourcesResourcesRetinal blind spotRiskRisk AssessmentRodentRodentiaRodents MammalsRoleSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 epidemicSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 pandemicSARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SeriesSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 pandemicSevere acute respiratory syndrome related corona virus 2Simian Hemorrhagic Disease VirusSimian hemorrhagic fever virusSuidaeSusceptibilitySwineSystemTestingTherapeuticThinnessTotal Human and Non-Human Gene MappingVaccinesVariantVariationViralViral DiseasesViral ReceptorVirionVirusVirus DiseasesVirus ParticleVirus ReceptorsWild AnimalsWuhan coronavirusZoonosesZoonoticZoonotic Infectionantibody receptorbiologicbiological systemscombatcorona viruscoronavirus disease 2019coronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 pandemiccoronavirus disease 2019 public health crisiscoronavirus disease 2019 viruscoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease pandemiccoronavirus disease-19coronavirus disease-19 global pandemiccoronavirus disease-19 pandemiccoronavirus disease-19 viruscoronavirus infectious disease-19developmentaldomesticated animalexperimentexperimental researchexperimental studyexperimentsgenetic mappinggenome mutationgenome scalegenome-widegenomewidehCoV19improvedlife coursemedical countermeasurenCoV2neglectneonatal Fc receptornon-human primatenonhuman primatenovelnovel virusoverexpressoverexpressionpandemic disease preparednesspandemic planningpandemic preparednesspandemic readinessparticlepermissivenessporcineprogramsreceptorreceptor functionsevere acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicskillssocial rolesuidtechnology platformtechnology systemtoolviral infectionvirus infectionvirus-induced diseasewell-beingwellbeing
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PROJECT SUMMARY/ABSTRACT
As COVID-19 has illustrated, the emergence of novel RNA viruses from wild animals poses a significant threat
to human health. In this proposal, we will begin to assess the zoonotic potential of an entire family of viruses:
the arteriviruses. The arteriviruses are the only mammalian RNA virus family not known to infect…
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