grant
Antigen recognition and activation of HIV-specific B cell antigen receptors
NIHUS FederalResearch GrantFY202519S Gamma Globulin7S Gamma GlobulinAIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAffinityAmino Acid MotifsAnimal ModelAnimal Models and Related StudiesAntibodiesAntibody SpecificityAntigen ReceptorsAntigenic DeterminantsAntigensAssayAutomobile DrivingB blood cellsB cellB cell receptorB cell repertoireB cellsB-Cell ActivationB-Cell Antigen ReceptorB-CellsB-LymphocytesB-cellBACH2BACH2 geneBTB and CNC Homology 2BackBasic Leucine Zipper Transcription Factor 2BindingBinding DeterminantsBinding SitesBioassayBiochemicalBiological AssayBiophysicsBlood Plasma CellBp50CD27 ligandCD27LCD32BCD40CD70 antigenCDW40Cell Communication and SignalingCell CompartmentationCell CompartmentationsCell LineCell SignalingCell membraneCell surfaceCellLineCombining SiteCompensationComplexCouplingCytoplasmic MembraneDNA mutationDevelopmentDorsumEpitopesEventFCG2FCGR2FCGR2BFCGR2B geneFloorFrequenciesGenetic ChangeGenetic defectGenetic mutationGerm LinesGerminal CenterGlycansGoalsGrantHIVHIV AntigensHIV ReceptorsHIV envelopeHIV envelope proteinHIV-1HIV-1 vaccineHIV-Associated AntigensHIV-IHIV1HIV1 vaccineHTLV-III AntigensHTLV-III ReceptorsHTLV-III-LAV AntigensHumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III AntigensHuman immunodeficiency virus 1IgGIgMImmunizationImmunochemical ImmunologicImmunoglobulin GImmunoglobulin MImmunologicImmunologicalImmunologicallyImmunologicsIntracellular Communication and SignalingKI miceKineticsKnock-in MouseLAV AntigensLAV-HTLV-IIILigandsLightLymphadenopathy-Associated AntigensLymphadenopathy-Associated VirusMGC9013MeasurementMemoryMemory B CellMemory B-LymphocyteModelingModern ManMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMutationPhotoradiationPhysiologicPhysiologicalPlasma CellsPlasma MembranePlasmacytesPlayPolysaccharidesPreclinical TestingPropertyProtein MotifsReactive SiteReceptor ActivationReceptor ProteinRegulationResolutionRoleSignal TransductionSignal Transduction SystemsSignalingSpecificityStrains Cell LinesStructure of germinal center of lymph nodeTNFRSF5TNFRSF5 geneTestingTumor Necrosis Factor Receptor Superfamily Member 5 GeneVaccinatedViral Gene ProductsViral Gene ProteinsViral ProteinsViral VaccinesVirus-HIVWorkactivated B cellsanti-viral developmentanti-viral drug developmentanti-viral therapeutic developmentanti-viral therapy developmentantigen bindingantigen boundantiviral developmentantiviral drug developmentantiviral therapeutic developmentantiviral therapy developmentbiological signal transductionbiophysical characteristicsbiophysical characterizationbiophysical foundationbiophysical measurementbiophysical parametersbiophysical principlesbiophysical propertiesbiophysical sciencesconformationconformationalconformational stateconformationallyconformationscultured cell linedesigndesigningdevelop a vaccinedevelop vaccinesdeveloping anti-viral agentdeveloping anti-viral drugdeveloping anti-viral therapeuticdeveloping anti-viral therapydeveloping antiviral agentdeveloping antiviral drugdeveloping antiviral therapeuticdeveloping antiviral therapydevelopment of a vaccinedevelopmentaldrivinggenome mutationimmunogenin vivoknockin micemodel of animalmouse modelmurine modelneutralizing antibodyp50plasmalemmaplasmocytepre-clinical testingprogramsreceptorrecruitresolutionsresponsesocial rolevaccine developmentvirus protein
Description preview
Abstract
B cell antigen receptor (BCR)-antigen interactions that govern the activation of B cells with a pre-vaccinated B-
cell repertoire are not clearly defined for HIV-1 broadly neutralizing antibody (bnAb) lineages. Our recent studies
show that B cell activation is dependent on antigen-binding association rate and not on the overall affinity…
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