grant
Antibody-protein conjugates as inhibitors of HIV/AIDS
Organization NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AIDS VirusAIDS/HIVAb-dependent cellular cytotoxicityAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAffinityAnimal ModelAnimal Models and Related StudiesAnimalsAntibodiesAssayBindingBioassayBiologicalBiological AssayBlood PlasmaCD34CD34 geneCell BodyCellsCellular Immune FunctionClinicalCommon Rat StrainsComplement-Dependent CytotoxicityD-MannoseDevelopmentDoseDrug KineticsE coliE. coliEngineeringEscherichia coliFc ReceptorFc domainFcRnFcRn neonatal transfer proteinGlycansGlycoproteinsGoalsHIVHIV Envelope Glycoprotein gp120HIV Envelope Protein gp120HIV InfectionsHIV env Protein gp120HIV envelopeHIV envelope proteinHIV/AIDSHPCA1HTLV-III InfectionsHTLV-III gp120HTLV-III-LAV InfectionsHalf-LifeHourHumanHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsIgG1ImmuneImmune responseImmunesImmunityIn VitroInfectionLAV-HTLV-IIILectinLymphadenopathy-Associated VirusMammalian CellMannopyranoseMannopyranosideMannoseMediatingMetabolic GlycosylationModern ManMolecularMolecular InteractionMucosaMucosal TissueMucous MembranePharmacokineticsPlasmaPlasma SerumPolysaccharidesProteinsPublishingRatRats MammalsRattusReceptor ProteinRecyclingResearchReticuloendothelial System, Serum, PlasmaSystemTestingTherapeuticTimeVirusVirus-HIVWorkantibody dependent cell mediated cytotoxicityantibody dependent cytotoxicityantibody mediated cellular cytotoxicityantibody receptorantibody-dependent cell cytotoxicityantibody-dependent cellular cytotoxicityantibody-mediated cytotoxicitybiologiccomplement-mediated cytotoxicitydesign and constructdesign and constructiondesign validationdesign verificationdevelopmentalglycosylationgp120gp120 ENV Glycoproteingp120(HIV)host responsehumanized micehumanized mouseimmune functionimmune system responseimmunoresponsein vivoinhibitormanufacturabilitymodel of animalmonomermouse modelmurine modelneonatal Fc receptornovelpreventpreventingreceptorresponsescale up
Description preview
During FY2025 we achieved a major milestone in the development of glycan-targeting antibody-lectin conjugates by demonstrating, for the first time, in vivo protection from HIV challenge in a humanized mouse model. Building on previous work, we engineered and tested monomeric griffithsin (mGRFT) fused to the Fc domain of human IgG1 (mGRFT-Fc). Two…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click