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Anatomically Guided Sodium MRI: Accurately Monitoring Chronic Ion Pump Dysfunction in the Human Brain

Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 May 2022Deadline 31 Jan 2026 ⚠️
NIHUS FederalResearch GrantFY2025AbscissionActive Follow-upAddressAdvocateAnatomic SitesAnatomic structuresAnatomyAutoregulationBayesian MethodBayesian MethodologyBayesian Statistical MethodBayesian approachesBayesian classification methodBayesian classification procedureBayesian posterior distributionBiochemicalBiological MarkersBody TissuesBrainBrain NeoplasiaBrain NeoplasmsBrain Nervous SystemBrain TumorsBrain imagingBrain scanCNS DiseasesCNS Nervous SystemCNS disorderCell Communication and SignalingCell NucleusCell SignalingCentral Nervous SystemCentral Nervous System DiseasesCentral Nervous System DisordersCerebrospinal FluidChronicClinicalClinical EvaluationClinical ProtocolsClinical TestingCommunitiesCouplingDataDetectionDevelopmentDiagnosisDysfunctionEncephalonEnergy ExpenditureEnergy MetabolismEnvironmentEvaluationExcisionExtirpationFunctional disorderGenerationsGoalsH+ elementHomeostasisHumanHydrogen IonsImageInterventionIntracellular Communication and SignalingIon PumpsLesionMR ImagingMR TomographyMRIMRI ScansMRIsMagnetic Resonance ImagingMagnetic Resonance Imaging ScanMapsMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodologyModern ManMonitorNMR ImagingNMR TomographyNa elementNa pumpNa(+)-K(+)-Exchanging ATPaseNa+ K+ ATPaseNa+ elementNatureNeuraxisNoiseNuclear Magnetic Resonance ImagingNucleusPETPET ScanPET imagingPETSCANPETTPathologicPathologyPatientsPerformancePhysiological HomeostasisPhysiopathologyPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPotassium ATPase SodiumPotassium Adenosinetriphosphatase SodiumPotassium PumpPropertyProtocolProtocols documentationProtonsRad.-PETRelaxationRemovalResearchResolutionSchemeSignal TransductionSignal Transduction SystemsSignalingSliceSodiumSodium PumpSodium-Potassium PumpSurgical RemovalSystemTechniquesTissuesValidationZeugmatographyactive followupbio-markersbiologic markerbiological signal transductionbiomarkerbrain tissuebrain visualizationcerebral spinal fluidclinical implementationclinical relevanceclinical testclinically relevantdata acquisitiondata acquisitionsdetection sensitivitydevelopmentalexperiencefollow upfollow-upfollowed upfollowupgray matterhuman imagingimage constructionimage generationimage reconstructionimagingimaging systemimprovedin vivomagnetic fieldneural imagingneuro-imagingneuroimagingneurological imagingnew approachesnovelnovel approachesnovel strategiesnovel strategypathophysiologypositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographyreconstructionresearch clinical testingresectionresolutionssodium ionsodium potassium exchanging ATPasespinal fluidsubstantia albasubstantia griseasuccesstissue biomarkerstumors in the brainvalidationswhite matter

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Description preview

PROJECT SUMMARY:
This proposal is devoted to the development, clinical implementation and evaluation of a novel, methodology
for generating brain sodium images of unparalleled resolution and signal-to-noise-ratio. This methodology is a
result or recent developments in Bayesian image reconstruction and manifold mapping techniques that
together make…

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