grant
Analysis of the AgrA-mediated transcription regulation in Listeria monocytogenes
Organization TUFTS UNIVERSITY BOSTONLocation BOSTON, UNITED STATESPosted 18 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY20260-4 weeks oldAddressAffectAffinity ChromatographyAssayAutoregulationBacteriaBasal Transcription FactorBasal transcription factor genesBindingBinding ProteinsBinding SitesBioassayBiological AssayBranched-Chain Amino AcidsCell BodyCell Communication and SignalingCell DensityCell SignalingCellsChIP SequencingChIP-seqChIPseqCombining SiteComplementComplement ProteinsComplexCoupledDNADNA BindingDNA Binding InteractionDNA analysisDNA boundDNase-I FootprintingDeoxyribonucleic AcidDependenceDevelopmentDiseaseDisorderElderlyEnvironmentEnzyme GeneEnzymesFoundationsGTPGene ExpressionGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGenetic TranscriptionGenomicsGoalsGram-Positive BacteriaGrowthGuanosine TriphosphateHomeostasisHumanImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunosuppressed HostIn VitroIndividualInfectionIntermediary MetabolismIntracellular Communication and SignalingL monocytogenesL. monocytogenesLaboratoriesLigand Binding ProteinLigand Binding Protein GeneListeria monocytogenesLocationMasksMassive Parallel SequencingMassively Parallel DNA SequencingMassively Parallel SequencingMediatingMetabolic ProcessesMetabolismMicrobial BiofilmsModelingModern ManMolecular InteractionNewborn InfantNewbornsNucleotidesOrganismPathogenicityPatternPeptide Signal SequencesPhenotypePhysiological HomeostasisPhysiologyPregnant WomenProcessProtein BindingProteinsRNA ExpressionRNA SeqRNA sequencingRNAseqReactive SiteRegulationResolutionRoleS aureusS. aureusSignal PathwaySignal PeptideSignal SequencesSignal TransductionSignal Transduction SystemsSignalingSiteStaph aureusStaphylococcus aureusSystemTestingTherapeutic InterventionTissue GrowthTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationUnited StatesVirulenceVirulentVisualizationWorkadvanced ageaffinity purificationanalyze DNAbacteria pathogenbacterial pathogenbiofilmbiological signal transductionbound proteinbranched amino acidschromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcomplementationdevelopmentalexpectant motherexpectant womenexpecting motherexpecting womenexperimentexperimental researchexperimental studyexperimentsextracellularfood born pathogenfood borne pathogenfood-bornfood-born illnessfood-bornefood-borne diseasefood-borne illnessfoodbornfoodborn illnessfoodborn pathogenfoodbornefoodborne diseasefoodborne illnessfoodborne pathogengenome scalegenome wide analysisgenome wide studiesgenome-widegenome-wide analysisgenome-wide identificationgenomewidegeriatrichigh definitionhigh-resolutionhistidine kinaseimmunosuppressed patientin vivoindividuals who are pregnantinsightintervention therapyliving systemmutantnew approachesnewborn childnewborn childrennovelnovel approachesnovel strategiesnovel strategyontogenypathogenpathogenic bacteriapathogenicity genepeople who are pregnantpregnant femalespregnant motherspregnant peoplepregnant populationspromoterpromotorprotein purificationprotein signal sequenceprotein-histidine kinasequorum sensingresolutionsresponsesenior citizensensor histidine kinasesocial rolethose who are pregnanttranscription factortranscriptome sequencingtranscriptomic sequencingvirulence genevirulent genewomen who are pregnant
Description preview
Abstract. Listeria monocytogenes is a low G+C Gram-positive bacterium that can cause severe disease in
immunocompromised individuals, pregnant women, newborns, and the elderly. Pathogenic strains frequently
use two-component regulatory systems to control the timing and level of virulence gene expression. In L.
monocytogenes, a quorum-sensing-like…
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