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Analysis of oxidative stress through deep atomic embeddings

Organization VANDERBILT UNIVERSITYLocation Nashville, UNITED STATESPosted 30 Sept 2024Deadline 8 Jan 2026 ⚠️
NIHUS FederalResearch GrantFY2025AD dementiaAI based methodAI systemAcetylationAgeAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAmino AcidsArchitectureArtificial IntelligenceAttentionBenchmarkingBest Practice AnalysisBinding SitesBiochemicalBiochemical PhenomenaBioinformaticsCarbohydratesCase StudyCell BodyCellsCollaborationsCombining SiteCommunitiesComplementComplement ProteinsComplexComputer ReasoningCysteineDataData BasesData SetDatabasesDevelopmentDiseaseDisorderDrug TargetingDrugsEngineering / ArchitectureEnsureEnvironmentExposure toFaceFutureGeometryGraphHalf-CystineHumanIndividualL-CysteineLengthLigand BindingLigandsLipidsMachine IntelligenceMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMedicationMethodologyMethodsModelingModern ManModificationMolecularNucleotidesOxidantsOxidative StressOxidizing AgentsPathway interactionsPersonsPharmaceutical PreparationsPhosphorylationPost Translational Modification AnalysisPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPrimary Senile Degenerative DementiaProceduresProtein BiochemistryProtein ModificationProtein PhosphorylationProtein/Amino Acid BiochemistryProteinsProteomeReactive SiteResearchResolutionScanningSchemeScientistSiteSourceSpecific qualifier valueSpecifiedStructureSurvey InstrumentSurveysTrainingWorkage related pathwaysagesaging associatedaging associated diseaseaging associated disordersaging associated mechanismaging mechanismaging pathwayaging relatedaging related diseaseaging related disordersaging related mechanismaging related pathwaysaminoacidartificial intelligence methodautoencoderautoencoding neural networkbenchmarkbiological mechanism of agebiological pathways of agecase reportcohortcomplementationcostdata basedeep learningdeep learning methoddeep learning strategydesigndesigningdetection methoddetection proceduredetection techniquedevelopmentaldisease associated with agingdisease of agingdisorder of agingdisorders associated with agingdisorders related to agingdrug/agentelectron acceptorfacesfacialhallmarks of aginginsightinterestlab assignmentlab experimentlaboratory activitylaboratory assignmentlaboratory exerciselaboratory experimentmechanism regulating agingmechanisms involved in agingmethod developmentneural networknoveloxidationoxidative damageoxidative injurypathwaypathway involved in agingpillars of agingprimary degenerative dementiaprotein functionprotein structureprotein structuresproteins structureresolutionssenile dementia of the Alzheimer typetherapeutic agent developmenttherapeutic developmenttherapeutic targettoolvector

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PROJECT SUMMARY
This project aims to computationally assess the impact aging-related oxidative stress has on the human
proteome via a novel deep learning methodology. As a person ages, oxidative damage accumulates within their
cells through exposure to both endogenous and exogenous sources. While the correlation between oxidative
damage and aging…

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Analysis of oxidative stress through deep atomic embeddings — VANDERBILT UNIVERSITY | UNITED STATES | Sept 2024 | Dev Procure