grant
An organ on-a-chip model of oral cancer and bone invasion
Organization OREGON HEALTH & SCIENCE UNIVERSITYLocation PORTLAND, UNITED STATESPosted 1 Jul 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAddressAdventitial CellAttentionBiologicalBiologyBlood capillariesBody TissuesBone CarcinomaBone MatrixBone SurfaceBone TissueBone TumorBone neoplasmsCalcifiedCancersCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell-to-Cell InteractionCellsChemicalsClinicalCommunicationComplexComplex VariablesDeglutitionDentalDental ResearchDiagnosisDrug usageDrugsEnsureEventFundingGeneralized GrowthGrowthGrowth AgentsGrowth FactorGrowth SubstancesHNSCCHead and Neck CancerHead and Neck CarcinomaHead and Neck Squamous Cell CarcinomaHealthHigh PrevalenceHistopathologyHumanImmuneImmunesIn SituIntracellular Communication and SignalingInvadedInvestigatorsKnowledgeLinkMalignant Head and Neck NeoplasmMalignant NeoplasmsMalignant Oral Cavity NeoplasmMalignant Oral Cavity TumorMalignant Oral NeoplasmMalignant TumorMechanicsMediatingMedicationMetastatic Carcinoma to the BoneMicrofluidicsMineralsModelingModern ManMolecular FingerprintingMolecular ProfilingMorbidityMouth CancerNanostructuresNatureOperative ProceduresOperative Surgical ProceduresOral CancerOral Cavity Squamous Cell CarcinomaOral squamous cell carcinomaOsseous NeoplasmOsseous TumorOsteoblastsOsteoclastsOsteocytesParacrine CommunicationParacrine SignalingPatientsPericapillary CellPericytesPerivascular CellPharmaceutical PreparationsPhysiologicPhysiologicalPlayProcessProteins Growth FactorsPubMedPublicationsQOLQuality of lifeResearchResearch PersonnelResearchersRoleRouget CellsSCCHNSamplingScientific PublicationSideSignal TransductionSignal Transduction SystemsSignalingSpeechSurgicalSurgical InterventionsSurgical ProcedureSurgical complicationSurvival RateSwallowingSystemTestingTherapeutic EffectTherapeutic InterventionTimeTissue ArraysTissue ChipTissue GrowthTissue MicroarrayTissuesToothTooth structureTumor CellTumor Cell InvasionTumor InvasionValidationVascularizationbiologicbiological signal transductionbonebone cellbone invasionbony invasioncalcificationcapillarychemo-/radio-therapychemo-radiotherapychemoradiationchemoradiation therapychemoradiation treatmentchemoradiotherapychemotherapychip modelchip systemclinical applicabilityclinical applicationclinical relevanceclinically relevantcraniofacialcraniofacial bonecraniofaciesdrug efficacydrug safetydrug usedrug/agenthead and neck squamous carcinomahead and neck squamous cell cancerhead/neck cancerhuman modelin vitro Modelintervention therapymalignancymalignant head and neck tumormalignant mouth neoplasmmalignant mouth tumormechanicmechanicalmedication safetymineralizationmodel of humanmolecular profilemolecular signaturemouth SCCmouth squamous cell carcinomamultiomicsmultiple omicsnano meter scalenano meter sizednano-sized structuresnano-structuresnanometer scalenanometer sizednanoscaleneoplasm/cancerneoplastic cellnew approachesnext generationnovel approachesnovel strategiesnovel strategyon a chipon chipontogenyoral cavity SCCoral cavity canceroral squamous canceroral squamous carcinomaorgan chiporgan on a chiporgan on chiposteoblast cell differentiationosteoblast differentiationosteoblastic differentiationosteoclastogenesispanomicsparacrinepharmaceutical safetyprecursor cellradio-chemo-therapyradio-chemotherapyradiochemotherapyresponseresponse to therapyresponse to treatmentscreeningscreeningssocial rolesurgerysurgery complicationsurvival outcometargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentteeththerapeutic responsetherapy responsethree dimensionaltooltreatment responsetreatment responsivenesstreatment strategyvalidationsvirtualµfluidic
Description preview
ABSTRACT
Head and neck squamous cell carcinoma is the sixth most common cancer worldwide with approximately 600,000 new
cases diagnosed each year. Oral squamous cell carcinoma (OSCC) in particular, poses a significant health challenge due to
its high prevalence and aggressive nature due to its propensity to invade bone. Therefore, elucidating…
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