grant
An Assay for Paenibacillus Detection in Low Resourced Settings
Organization PENNSYLVANIA STATE UNIV HERSHEY MED CTRLocation HERSHEY, UNITED STATESPosted 3 Apr 2026Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20260-11 years oldAccelerationAdmissionAdmission activityAffectAfricaAfrica South of the SaharaAntibiotic AgentsAntibiotic DrugsAntibiotic TherapyAntibiotic TreatmentAntibioticsAntibodiesAreaAssayBacteriaBioassayBiological AssayBiotechBiotechnologyBloodBlood Reticuloendothelial SystemBrainBrain Nervous SystemChildChild YouthChildren (0-21)ClinicClinicalClinical MicrobiologyClinical Treatment MoabClinical TrialsCollectionCommunicable DiseasesContracting OpportunitiesContractsDetectionDevelopmentDevice DesignsDevicesDiagnostic DeviceDiagnostic EquipmentDiseaseDisorderELISAEarly DiagnosisEarly InterventionEncephalonEnvironmentEnzyme-Linked Immunosorbent AssayEquipmentFollow-Up StudiesFreezingFundingGoalsGuidelinesHandHomeHospital ReferralsHydrocephalusHydrocephalyInfantInfectionInfectious DiseasesInfectious DisorderKenyaLaboratoriesLateralLow-resource areaLow-resource communityLow-resource environmentLow-resource regionLow-resource settingMiscellaneous AntibioticMonoclonal AntibodiesNeonatalNeonatal MortalityNorthern RhodesiaOrganismOutcomePathogen detectionPathogenicityPatientsPreparationPreventative measurePreventive measureProceduresProtocolProtocols documentationRegimenReportingResearch ResourcesResistanceResource-constrained areaResource-constrained communityResource-constrained environmentResource-constrained regionResource-constrained settingResource-limited areaResource-limited communityResource-limited environmentResource-limited regionResource-limited settingResource-poor areaResource-poor communityResource-poor environmentResource-poor regionResource-poor settingResourcesSamplingSensitivity and SpecificitySepsisSiteSourceSpecificitySub-Saharan AfricaSubsaharan AfricaSyndromeTestingTherapeuticTherapeutic InterventionTimeTrainingUgandaZambiaantisepsis treatmentbacteria pathogenbacterial disease treatmentbacterial infectious disease treatmentbacterial pathogencommercial scale manufacturingdeath among neonatesdeath among newbornsdeath due to sepsisdeath in neonatesdeath in newborndeath related to sepsisdevelopmentalearly detectioneffective therapyeffective treatmentenzyme linked immunoassayfield based datafield learningfield studyfield testfollow-up research studyfollow-up surveygold nano particlegold nanoparticlehandshealth care burdenhomeshydrocephalicindividuals with sepsisinfected neonateinfected newbornintervention therapykidsliving systemmAbsmanufacturemanufacturing ramp-upmanufacturing scale-upmigrationmonoclonal Absmortality among neonatesmortality among newbornsmortality associated with sepsismortality in neonatesmortality in newbornsmortality in sepsisnano goldnanoGoldneonatal deathneonatal demiseneonatal infectionneonatal morbidityneonatal sepsisneonateneurotropicnewborn deathnewborn infectionnewborn morbiditynewborn mortalitynovelpathogenpathogenic bacteriapatients with sepsispeople with sepsispoint of carepoint-of-care detectionpreparationsprototyperapid assayrapid detectionrapid testrapid testsresistance generesistance locusresistantresistant genescale up batchscale up productionsepsis associated deathsepsis associated mortalitysepsis caresepsis caused deathssepsis deathsepsis groupssepsis induced deathsepsis induced mortalitysepsis interventionssepsis lethalitysepsis managementsepsis mortalitysepsis patientssepsis populationsepsis related deathssepsis related mortalitysepsis subjectssepsis therapeuticssepsis therapysepsis treatmentseptic deathseptic groupseptic individualsseptic mortalityseptic patientsseptic peopleseptic populationseptic subjectseptic therapyseptic treatmentstudy with follow-upsubjects with sepsistargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttreat sepsisupscale manufacturinguser-friendlyyoungster
Description preview
An Assay for Paenibacillus Detection in Low Resourced Settings
We recently identified a novel bacterial pathogen, Paenibacillus thiaminolyticus, from neonatal sepsis patients
in Sub-Saharan Africa. The pathogen is highly selective for neonates, neurotropic and extremely lethal,
resulting in a syndrome we have termed paenibacilliosis. The pathogen…
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