grant
ALZHEIMERS RESEARCH PROJECT: The mean apparent propagator (MAP) MRI indices as neuroimaging biomarkers of cerebral aging, mild cognitive impairment, Alzheimers disease, and associated risk factors
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AD dementiaANCOVAAPOEAccelerationAccountingAffectAgeAgingAgreementAlcohol DrinkingAlcohol consumptionAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's biomarkerAlzheimer's disease biological markerAlzheimers DementiaAlzheimer’s biological markerAlzheimer’s disease biomarkerAmentiaAmyloidAmyloid (Aβ) plaquesAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid PlaquesAmyloid Protein A4Amyloid SubstanceAmyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAnalysis of CovarianceAnisotropyAnteriorApo-EApoE proteinApolipoprotein EArchitectureAttentionAxonAβBehaviorBiologic ModelsBiologicalBiological FunctionBiological MarkersBiological ModelsBiological ProcessBiologyBiomedical ResearchBiophysicsBlood VesselsBody TissuesBrainBrain Nervous SystemBrain regionCell membraneCerebrumCharacteristicsClinicalClinical TrialsCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalComplexCuriositiesCytoplasmic MembraneDWI (diffusion weighted imaging)DWI-MRIDataData SetDementiaDemyelinationsDepositDepositionDeteriorationDevelopmentDiffusionDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDiseaseDisorderDisturbance in cognitionEarly DiagnosisEarly InterventionEncephalonEngineering / ArchitectureEtOH drinkingEtOH useExhibitsFailureFiberGaussian modelGaussian statisticsGaussianityGaussianity modelGeneticGoalsHumanHydrogen OxideHypertensionImageImpaired cognitionIndividualInterventionInvestigatorsLinkLiquid substanceMR ImagingMR TomographyMRIMRIsMT-bound tauMagnetic Resonance ImagingMathMathematicsMeasurementMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMetabolicMethodologyMethodsMicroscopicMissionModel SystemModelingModern ManMolecularNMR ImagingNMR TomographyNerve DegenerationNeuritesNeuritic PlaquesNeurofibrillary TanglesNeuron DegenerationNuclear Magnetic Resonance ImagingObesityOrganellesOutcomePaperParticipantPathologicPathologyPhasePhysical activityPlasma MembranePreventionPrimary Senile Degenerative DementiaProbabilityProcessProtocolProtocols documentationR-Series Research ProjectsR01 MechanismR01 ProgramRadialRadiusRegression AnalysesRegression AnalysisRegression DiagnosticsReportingResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearchersRisk FactorsRoleSeminalSenile PlaquesSensitivity and SpecificitySeveritiesSmokingSpecificityStatistical RegressionStructureSynapsesSynapticTechniquesTechnologyTimeTissue ModelTissuesVascular Hypertensive DiseaseVascular Hypertensive DisorderVentricularWaterWorkZeugmatographya beta peptideabetaabnormally aggregated tau proteinaccurate diagnosisadiposityage associatedage associated alterationsage associated changesage associated diseaseage associated disorderage associated impairmentage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage dependent diseaseage dependent disorderage dependent impairmentage induced alterationsage induced changesage linkedage relatedage related alterationsage related changesage related human diseaseage specificage specific alterationsage specific changesage-related diseaseage-related disorderage-related impairmentagesaging associated alterationsaging associated changesaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging related alterationsaging related changesaging specific alterationsaging specific changesalcohol ingestionalcohol intakealcohol product usealcohol usealcoholic beverage consumptionalcoholic drink intakealterations with ageamyloid betaamyloid beta plaqueamyloid-b plaqueamyloid-b proteinanalyzing longitudinalaβ plaquesbeta amyloid fibrilbio-markersbiologicbiologic markerbiomarkerbiophysical foundationbiophysical principlesbiophysical sciencesbrain atrophycerebralcerebral atrophychanges with agecognitive defectscognitive dysfunctioncognitive losscored plaquecorpulencecortical atrophydMRIdemyelinatedensitydesigndesigningdevelopmentaldiffuse plaquediffuseddiffusesdiffusingdiffusion tensor imagingdiffusionsearly detectionethanol consumptionethanol drinkingethanol ingestionethanol intakeethanol product useethanol usefilamentous tau inclusionfluidgray matterhigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderimagingimaging biomarkerimaging markerimaging-based biological markerimaging-based biomarkerimaging-based markerimprovedindexinginsoluble aggregateinterestliquidlongitudinal analysislongitudinal designlongitudinal experimental designlongitudinal research designlongitudinal study designmalleable riskmicrotubule associated protein tau aggregationmicrotubule associated protein tau depositmicrotubule bound taumicrotubule-bound taumild cognitive disordermild cognitive impairmentmodifiable risknatural agingnerve cell deathnerve cell lossneural degenerationneural imagingneuro-imagingneurodegenerationneurodegenerativeneurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologyneuroimagingneuroimaging biomarkerneuroimaging markerneurological degenerationneurological imagingneuron cell deathneuron cell lossneuron deathneuron lossneuronal cell deathneuronal cell lossneuronal deathneuronal degenerationneuronal lossneuropathologicneuropathologicalneuropathologynon-Gaussian modelnon-Gaussianitynon-Gaussianity modelnormal agingnormative agingpaired helical filament of tauplasmalemmapreventpreventingprimary degenerative dementiaprotein aggregateprotein aggregationrate of changeself-aggregate tausenile dementia of the Alzheimer typesocial rolesoluble amyloid precursor proteinspecific biomarkerssubstantia albasubstantia griseasynapsetangletautau PHFtau Proteinstau accumulationtau aggregatetau aggregationtau factortau fibrillizationtau filamenttau neurofibrillary tangletau oligomertau paired helical filamenttau polymerizationtau-tau interactionvascularwhite matterτ Proteinsτ aggregation
Description preview
One of the current critical goals of biomedical research, in general, and the NIA’s mission, in particular, is to establish sensitive and specific biomarkers as indicators of Alzheimer’s disease (AD), especially during the prodromal phase of the disease, for accurate and early diagnosis, as well as for the design of targeted and rational…
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