grant
ALZHEIMERS RESEARCH PROJECT: CARD - Senescent Phenotypes of Isogenic iPSC-Derived Alzheimer's Disease and Related Dementia Models at Cellular Resolution
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY202514-HydroxydaunomycinAD dementiaAD related dementiaADAMTSADRDAdriamycineAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimers DementiaAssayAstrocytesAstrocytusAstrogliaBioassayBiological AssayCell AgingCell BodyCell Culture TechniquesCell SenescenceCell Senescence InductionCellsCellular AgingCellular SenescenceConditioned Culture MediaConditioned MediumDNA mutationDataData BasesData SetDatabasesDegenerative Neurologic DisordersDiseaseDisorderDoseDoxorubicinDoxorubicinaEngineeringExposure toFutureGene variantGenesGenetic ChangeGenetic DiversityGenetic RiskGenetic VariationGenetic defectGenetic mutationGliaGlial CellsHandHeritabilityHumanHydroxyl DaunorubicinHydroxyldaunorubicinImmunofluorescenceImmunofluorescence ImmunologicIndividualInvestigatorsKolliker's reticulumLaboratoriesLeadLinkMethodsModelingModern ManMutationNerve CellsNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurogliaNeuroglial CellsNeurologic Degenerative ConditionsNeuronsNon-neuronal cellNonneuronal cellOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellPb elementPhenotypePopulationPrimary Senile Degenerative DementiaProteinsProteomicsProtocolProtocols documentationR-Series Research ProjectsR01 MechanismR01 ProgramReplicative SenescenceResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearch ResourcesResearchersResolutionResourcesRiskRisk-associated variantSenotherapeuticStimulusStressTestingTransmissionVariantVariationWorkallelic variantastrocytic gliabrain cellcell culturecell culturescell typecellular aging inductioncellular senescence inductiondata basedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdepositorydrivers of agingextracellular vesiclesgenetic variantgenome mutationgenomic variantgerodriverhandsheavy metal Pbheavy metal leadhuman dataiPSiPSCiPSCsinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinsightmultiomicsmultiple omicsnerve cementneurodegenerative illnessneuronalpanomicsprimary degenerative dementiaprion-likereplicative agingrepositoryresolutionsrisk allelerisk generisk genotyperisk locirisk locusrisk variantsenescencesenescence and its associated secretory phenotypesenescence associated secretomesenescence associated secretory factorssenescence associated secretory pathwaysenescence associated secretory phenotypesenescence associated secretory programsenescence associated secretory proteinssenescence inductionsenescentsenescent associated secretomesenescent associated secretory phenotypesenescent cellsenile dementia of the Alzheimer typetranscriptomicstransmission process
Description preview
Toward our aim of developing a neuronal model to quantify and induce cellular senescence, we have explored senescence induction with two types of stimuli ad different doses: doxorubicin treatment and SLO treatment. We assessed senescence signatures using multiple methods: transcriptomic, proteomics, activity assays, and immunofluorescence. We show…
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