grant
Alzheimers Disease Project: Quantitative imaging of astrogliosis and neuroinflammation
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AD dementiaAD detectionAD pathologyAffectAgeAgingAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer disease detectionAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's detectionAlzheimer's diagnosisAlzheimer's disease diagnosisAlzheimer's disease pathologyAlzheimer's pathologyAlzheimers DementiaAmentiaAmmon HornAmyloidAmyloid (Aβ) plaquesAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid PlaquesAmyloid Protein A4Amyloid SubstanceAmyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAreaAstrocytesAstrocytusAstrogliaAstroproteinAutopsyAβBiologicalBiological MarkersBody TissuesBrainBrain Nervous SystemBrain PathologyBrain regionCNS Nervous SystemCell Communication and SignalingCell SignalingCentral Nervous SystemCerebrumChemicalsClinicalCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComplexCornu AmmonisDWI (diffusion weighted imaging)DWI-MRIDataDementiaDependenceDepositDepositionDetectionDevelopmentDiagnostic ImagingDiffusionDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDimensionsDisturbance in cognitionElasticityElderlyEncephalonEvaluationExhibitsFrequenciesFutureGFA-ProteinGFAPGlial Fibrillary Acid ProteinGlial Fibrillary Acidic ProteinGlial Intermediate Filament ProteinGoalsHippocampusHistologicHistologicallyHistologyHistopathologyHumanImageImaging DeviceImaging InstrumentImaging ToolImpaired cognitionIndividualInflammationIntracellular Communication and SignalingKnowledgeLesionLinkLiteratureMR ImagingMR TomographyMRIMRI biomarkerMRI markerMRIsMT-bound tauMagnetic Resonance ImagingMapsMeasurementMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodsMiceMice MammalsMicroscopicMicroscopyModalityModelingModern ManMurineMusMyelinNMR ImagingNMR TomographyNerve CellsNerve DegenerationNerve UnitNeural CellNeuraxisNeuritic PlaquesNeurocyteNeurofibrillary TanglesNeuron DegenerationNeuronal InjuryNeuronsNuclear Magnetic Resonance ImagingPETPET ScanPET imagingPETSCANPETTPatternPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPredictive ValuePrimary Senile Degenerative DementiaProceduresRad.-PETReactionRelaxationReproducibilityResearchResolutionSample SizeSamplingScanningSenile PlaquesSignal TransductionSignal Transduction SystemsSignalingSpecificityStructureSymptomsSystemTauopathiesTechniquesTemporal LobeTestingTimeTissue SampleTissuesTransgenic MiceValidationWild Type MouseWorkZeugmatographya beta peptideabetaabnormal brain functionadvanced ageage associatedage correlatedage dependentage linkedage relatedage specificagesamyloid betaamyloid beta plaqueamyloid-b plaqueamyloid-b proteinastrocytic gliaastrogliosisaβ plaquesbeta amyloid fibrilbio-markersbiologicbiologic markerbiological signal transductionbiomarkerbrain dysfunctionbrain impairmentbrain tissuecerebralcognitive dysfunctioncognitive losscohortcomputer based predictioncored plaquedMRIdementeddevelopmentaldiffuse plaquediffuseddiffusesdiffusingdiffusion anisotropydiffusion tensor imagingdiffusionsdigitaldysfunctional brainearly biomarkersearly detection biomarkersearly detection markersgeriatricglial activationglial cell activationgray matterhippocampalimage registrationimage-based methodimagingimaging biomarkerimaging in vivoimaging markerimaging methodimaging modalityimaging-based biological markerimaging-based biomarkerimaging-based markerimprovedin vivo imaginginjury responseinjury to tissueinnovateinnovationinnovativeinterestmachine learning based prediction modelmachine learning based predictive modelmachine learning predictionmachine learning prediction modelmagnetic resonance imaging biomarkermagnetic resonance imaging markermembermetermicroscope imagingmicroscopic imagingmicroscopy imagingmicrotubule bound taumicrotubule-bound taumillimetermouse modelmulti-modalitymultimodalitymurine modelnecropsyneural degenerationneural imagingneural inflammationneuro-imagingneurodegenerationneurodegenerativeneurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologyneuroimagingneuroinflammationneuroinflammatoryneurological degenerationneurological imagingneuron injuryneuronalneuronal degenerationneuropathologicneuropathologic tauneuropathologicalneuropathological tauneuropathologynon-dementednon-invasive imagingnondementednoninvasive imagingnovelp-taup-τphospho-tauphospho-τphosphorylated taupositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypost-translational modification of taupostmortemposttranslational modification of taupre-clinicalpreclinicalpredictive modelingprimary degenerative dementiaquantitative imagingresilienceresilientresolutionsresponseresponse to injurysenile dementia of the Alzheimer typesenior citizensoluble amyloid precursor proteinspatial and temporalspatial temporalspatiotemporalsubstantia albasubstantia griseatangletautau Proteinstau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neuropathologytau pathologytau pathophysiologytau phosphorylationtau posttranslational modificationtau proteinopathytau related neurodegenerationtau-1tau-induced pathologytauopathic neurodegenerative disordertauopathytemporal cortextime usetissue injurytoolvalidationsvirtualwhite matterwildtype mouseτ Proteinsτ phosphorylation
Description preview
As indicated in the Goals and Objectives section, the main goals of this research initiative are to discover diagnostic imaging biomarkers for astrogliosis and neuroinflammation by investigating the relationships between advanced MD-MRI signal signatures and increased glial fibrillary acidic protein (GFAP) deposition. Below, milestones from this…
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