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Alleviation of chronic TBI through modulation of calcium signaling
Organization U.S. DEPT/VETS AFFAIRS MEDICAL CENTERLocation WASHINGTON, UNITED STATESPosted 1 Oct 2023Deadline 31 Mar 2026 ⚠️
VANIHUS FederalResearch GrantFY2026Adenohypophyseal HyposecretionAdenohypophysisAffectAfghanistanAgonistAnterior Pituitary GlandAnterior Pituitary Hyposecretion SyndromeAnterior pituitaryAnxietyAreaAttenuatedBehaviorBehavioralBlood SerumBontoxilysinBotulinBotulinum ToxinsBrainBrain Nervous SystemBrain TraumaBrain regionCalcium Ion SignalingCalcium SignalingCalcium ionCell BodyCell Communication and SignalingCell SignalingCell SurvivalCell ViabilityCellsChronicClinicalClostridium botulinum ToxinsCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCommon Rat StrainsComplexCyclic SomatostatinDataDiagnostic FindingsDiseaseDisorderDisturbance in cognitionDysfunctionEncephalonEndocrine Gland SecretionFatigueFeedbackFunctional disorderFutureGHRHGRHGeneticGoalsGrowth HormoneGrowth Hormone 1Growth Hormone Inhibiting FactorsGrowth Hormone-Inhibiting HormoneGrowth Hormone-Releasing FactorGrowth Hormone-Releasing HormoneHormonalHormone Replacement RxHormone replacement therapyHormone secretionHormonesHuman Growth HormoneHypophysisHypophysis CerebriHypopituitarismHypothalamic structureHypothalamusImageImpaired cognitionImpairmentInflammationInflammatory ResponseInjuryIntracellular Communication and SignalingInvestigationInvestigatorsIon ChannelIonic ChannelsIraqLack of EnergyMeasuresMediatingMedicalMedical RehabilitationMembrane ChannelsMemoryMemory DeficitMemory impairmentMental DepressionMiceMice MammalsModelingMolecularMurineMusNSF attachment protein receptorNatural regenerationNerve CellsNerve UnitNeural CellNeurocyteNeuroendocrineNeuroendocrine SystemNeuronal InjuryNeuronsNeurosecretory SystemsOutcomeOxidative StressPars Anterior Pituitary GlandPathogenesisPathway interactionsPatientsPatients with traumatic brain injuryPhysiopathologyPituitaryPituitary GlandPituitary Growth HormonePituitary Nervous SystemPituitary insufficiencyPost-traumatic growthPosttraumatic growthProcessProteinsPublishingQOLQOL improvementQuality of lifeRatRats MammalsRattusReagentReceptor ProteinRecoveryRegenerationRehabilitationRehabilitation therapyResearch PersonnelResearch ResourcesResearchersResourcesRoleSNAP receptorSNARESRIHSRIH-14SeriesSerumSignal TransductionSignal Transduction SystemsSignalingSigns and SymptomsSiteSomatocrininSomatoliberinSomatostatinSomatostatin-14SomatotropinSomatotropin Release Inhibiting FactorsSomatotropin Release-Inhibiting HormoneSomatotropin-Releasing HormoneSurvivorsSynaptic VesiclesTBI PatientsTRP channelTestingTherapeuticTimeTransient receptor potential channelTraumatic Brain InjuryVesicleVeteransWalkingWarattenuateattenuatesaxon damageaxon growthaxon injuryaxon regenerationaxonal damageaxonal growthaxonal injuryaxonal regenerationbehavior studybehavior testbehavioral studybehavioral testbiological signal transductionbotulinum neurotoxincognitive dysfunctioncognitive losscontrolled cortical impactdepressionexperimentexperimental researchexperimental studyexperimentsfunctional restorationghrelingrowth hormone deficiencygrowth hormone release inhibiting factorhGHhormonal secretionhypothalamichypothalamic pituitary axisimagingimprovedimprovements in QOLimprovements in quality of lifeinjuredinjuriesinnovateinnovationinnovativelocomotor learningmemory dysfunctionmorris water mazemorris watermazemotor learningmouse modelmurine modelneurobehavioralneurochemicalneurochemistryneuron injuryneuronalneurotropicnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypatch clamppathophysiologypathwaypharmacologicpituitary anterior lobepituitary gland anterior lobepostsynapticprotein complexpsychologicpsychologicalquality of life improvementreceptorregeneraterehab therapyrehabilitativerehabilitative therapyrepairrepairedrestorationrestore functionrestore functionalityrestore lost functionside effectsite targeted deliverysocial rolesoluble N-ethylmaleimide-sensitive-factor attachment protein receptorsomatotropic hormonetargeted deliverytechnology platformtechnology systemtooltraumatic brain damagetraumatic brain injury patients
Applications closed.
Description preview
Project Summary: Growth hormone deficiency (GHD) due to chronic traumatic brain injury (TBI) is common
among the veterans from the wars in Iraq and Afghanistan. Such condition develops as a result of
hypothalamic-pituitary axis (HPA) dysfunction leading to reduced growth hormone (GH) levels, which pose a
significant impact on their quality of life…
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