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Allergen-elicited signaling cascades in olfactory microvillous tuft cells
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 3 Jun 2024Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY2025AcetylcholineAfferent NeuronsAirAirway mucosaAllergensAllergicAllergic DiseaseAlternariaAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryApicalAsthmaAutoregulationBronchial AsthmaCell BodyCell Communication and SignalingCell LineCell SignalingCellLineCellsChronicCoughingCys-LTDetectionDinoprostoneEicosanoidsEpithelial CellsEpitheliumEventFamilyFluorescenceFoundationsGenerationsGoalsGustationHomeostasisHumanImageImmuneImmunesIn VitroInflammationInflammation MediatorsInflammatoryInflammatory ResponseInhalationInhalingIntracellular Communication and SignalingLTRPC5LigandsLong Transient Receptor Potential Channel 5MLSN1- and TRP-Related Gene 1MTR1MapsMediatorMiceMice MammalsModern ManMucociliary ClearanceMucociliary TransportMucosaMucosal TissueMucous MembraneMurineMusNasalNasal MucosaNasal Passages NoseNerve CellsNerve UnitNeural CellNeurocyteNeuronsNoseOlfactory Epithelial CellOlfactory EpitheliumOlfactory MucosaOlfactory PathwaysOlfactory systemOrganPGD2PGE2PGE2 alphaPGE2alphaParticulate MatterPathway interactionsPhenotypePhysiological HomeostasisPopulationPositionPositioning AttributeProgenitor CellsProstaglandin D2Prostaglandin E2Prostaglandin E2 alphaProstaglandin E2alphaProstaglandinsProstanoidsPublishingPulmonary Body SystemPulmonary Organ SystemReceptor CellReceptor ProteinRespiratory EpitheliumRespiratory MucosaRespiratory SystemRespiratory System, Nose, Nasal PassagesRespiratory TractsRespiratory tract structureRoleSensorySensory NeuronsSignal InductionSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteSneezingSpecialized Epithelial CellStrains Cell LinesStressStructure of mucous membrane of noseStructure of respiratory epitheliumSuccinatesSurfaceSystemTRPM5TRPM5 geneTasteTaste BudsTaste PerceptionTechniquesTimeTracheaTrachea ProperTransient Receptor Potential Cation Channel, Subfamily M, Member 5Workaeroallergensairborn allergenairborne allergenairway epitheliumairway epithelium inflammationairway inflammationallergen responseallergic responseallergy responsebiological signal transductioncell typechronic rhinosinusitiscultured cell linecysteinyl-leukotrienecytokinegustatory perceptiongustatory processinggustatory responsehealingimagingimaging systeminflammatory mediatorlipid mediatormemberneuroepitheliumneuronalolfactory circuitryolfactory circuitsolfactory sensory neuronspathwayprogenitor cell poolprogenitor cell populationprogenitor cell proliferationprogenitor poolprogenitor populationprogenitor proliferationprogramsreceptorrespiratoryrespiratory inflammationrespiratory tract epitheliumrespiratory tract inflammationresponsescRNA sequencingscRNA-seqsensorsensory systemsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestem and progenitor cell populationstem and progenitor cell proliferationstem cell poolstem cell populationstem cell proliferationstem cellssynergismtaste processingtaste receptortaste responsetherapeutic targettime usetoolwindpipe
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Description preview
PROJECT SUMMARY:
The nasal mucosa consists of two distinct compartments - olfactory neuroepithelium and respiratory
epithelium. As such, the nose serves as both a respiratory and as a sensory organ. Among the epithelial cells
strategically positioned at the apical surface at the site of interaction with the inhaled air in the olfactory and…
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