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Aligned and electrically conductive collagen scaffolds for guiding innervated muscle-tendon junction repair of volumetric muscle loss injuries
Organization UNIVERSITY OF VIRGINIALocation CHARLOTTESVILLE, UNITED STATESPosted 1 May 2021Deadline 31 Mar 2026 β οΈ
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DACh ReceptorsAblationAcetylcholine ReceptorsAddressAnimalsAnterior Tibial MuscleAntibodiesBiocompatible MaterialsBiologicalBiological MimeticsBiomaterialsBiomechanicsBiomimeticsBioreactorsBody TissuesCell BodyCell Communication and SignalingCell MaturationCell SignalingCell SurvivalCell ViabilityCell-Extracellular MatrixCellsCholinergic ReceptorsCholinoceptive SitesCholinoceptorsCicatrixClinicalCo-cultureCocultivationCocultureCoculture TechniquesCollagenCommon Rat StrainsComplexConfocal MicroscopyConnective TissueCoriumCuesCutisCytoskeletal ModelingCytoskeletal OrganizationCytoskeletal Organization ProcessCytoskeletal ReorganizationDefectDenervationDermisDevelopmentE-stimECMElectric ConductivityElectric StimulationElectrical ConductivityEngineeringExtracellular MatrixFibrosisFunctional RegenerationGaitGait AnalysisGenerationsGlycosaminoglycansHistologicHistologicallyImageImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImplantIn VitroInjuryIntracellular Communication and SignalingLocomotionMeasurementMeasuresMechanical StimulationMechanicsModelingMovementMucopolysaccharidesMuscleMuscle AtrophyMuscle FibersMuscle TissueMuscle functionMuscular AtrophyMyoneural JunctionMyosin Heavy ChainsMyotubesNatural regenerationNerveNerve CellsNerve TissueNerve UnitNervous System InjuriesNervous System TraumaNervous System damageNervous TissueNeural CellNeural Stem CellNeurocyteNeurological DamageNeurological InjuryNeurological traumaNeuromuscular JunctionNeuronal DifferentiationNeuronsOperative ProceduresOperative Surgical ProceduresPatientsPeripheral NervesPeripheral Nervous SystemProcessProliferatingRatRats MammalsRattusRecovery of FunctionRegenerationRepair ComplexRhabdomyocyteScarsSignal TransductionSignal Transduction SystemsSignalingSkeletal FiberSkeletal MuscleSkeletal Muscle CellSkeletal Muscle FiberSkeletal MyocytesSkeletal muscle injurySkeletal systemStructureSurgicalSurgical InterventionsSurgical ProcedureTechnologyTendon structureTendonsTestingTherapeuticTissue EngineeringTissuesTransmissionTraumaVascularizationVoluntary MuscleWorkbeta Tubulinbioengineered tissuebiologicbiological materialbiological signal transductionbiomechanicalbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical parametersbiophysical propertiesbody movementclinical relevanceclinically relevantcollagen scaffoldconditioningdesigndesigningdevelopmentalelectrical conductanceelectrical potentialelectrostimulationengineered tissueexperiencefunctional improvementfunctional recoverygait examinationimagingimmunocytochemistryimprove functionimprovedimproved functional outcomesin vivoinjuriesinnervationinnovateinnovationinnovativemechanicmechanicalmicrobioreactormilitary patientmuscle breakdownmuscle degradationmuscle deteriorationmuscle fiber repairmuscle lossmuscle progenitormuscle progenitor cellmuscle regenerationmuscle repairmuscle stem cellmuscle tissue repairmuscle wastingmuscularmuscular repairmyogenesismyosin heavy chainneglectnerve stem cellnerve supplyneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurogenic progenitorsneurogenic stem cellneuron progenitorsneuronalneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitorneurotraumaosteochondralosteochondral tissuepatient populationpreconditioningprogenitor and neural stem cellsprogenitor cell differentiationprogenitor differentiationregenerateregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissuerepairrepair strategyrepairedrestorationscaffoldscaffoldingstem and progenitor differentiationstem cell differentiationsuccesssurgerythree dimensionaltibialis anteriortibialis anterior muscletissue regenerationtissue regrowthtissue renewaltissue repairtissue specific regenerationtransmission processvolumetric muscle lossΞ²-Tubulin
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ABSTRACT
Volumetric muscle loss (VML) injuries are debilitating traumas that result in permanent loss of muscle function.
Moreover, VML injuries are often compounded by damage to multiple tissues including connective and nervous
tissue. Peripheral nervous system damage can result in denervation that limits force generation while the
disruption ofβ¦
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