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Alcohol-Induced Metabolome-Epigenome Dysfunction and Alzheimer’s Disease Risk
Organization UNIVERSITY OF IOWALocation IOWA CITY, UNITED STATESPosted 1 May 2025Deadline 2 Jun 2025 ⚠️
NIHUS FederalResearch GrantFY2025AD dementiaAD modelAD pathologyALDHATAC sequencingATAC-seqATACseqAbsolute ethanolAccelerationAddressAffectAgeAgingAlcohol Chemical ClassAlcohol DrinkingAlcohol consumptionAlcoholismAlcoholsAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's disease modelAlzheimer's disease pathologyAlzheimer's disease riskAlzheimer's pathologyAlzheimers DementiaAmmon HornAssay for Transposase-Accessible Chromatin using sequencingAstrocytesAstrocytusAstrogliaAwardBrainBrain Nervous SystemBusiness-Friendly AtmosphereCASP-14CarbohydratesCell BodyCell NucleusCellsChromatinChronicCognitive deficitsComplexCornu AmmonisDNA Molecular BiologyDNA mutationDevelopmentDisease ProgressionDysfunctionETOHEast AsiaEastern AsiaEncephalonEnergy ExpenditureEnergy MetabolismEnsureEnzyme GeneEnzymesEpidemiologyEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEtOH drinkingEtOH useEthanolEthanol MetabolismEthyl AlcoholExhibitsFar EastFatsFatty acid glycerol estersFemaleFlushingFoundationsFunctional disorderGC MSGCMSGas-Liquid-Mass Spectrometry ChromatographyGene DeregulationGene ExpressionGenetic ChangeGenetic defectGenetic mutationGoalsGrain AlcoholGrantHippocampusHomeHumanHuman GeneticsImpairmentIndirect CalorimetryIndividualInhalationInhalingIntermediary MetabolismInterviewInvestigationInvestigatorsIowaKI miceKO miceKnock-in MouseKnock-out MiceKnockout MiceKnowledgeLaboratoriesLinkLipidsLow Molecular Weight Nuclear RNAMICE enzymeMT-bound tauMass FragmentographiesMass FragmentographyMass-Gas Chromatography SpectrometryMass-Gas Chromatography Spectrum AnalysisMemoryMentorsMetabolicMetabolic DiseasesMetabolic DisorderMetabolic ProcessesMetabolic dysfunctionMetabolismMethylcarbinolMiceMice MammalsMitochondriaModelingModern ManMolecular BiologyMolecular FingerprintingMolecular ProfilingMurineMusMutationNerve CellsNerve UnitNeural CellNeurocyteNeuronsNuclearNucleusNull MouseOncogene DeregulationPathway interactionsPatientsPeer ReviewPhasePhysiopathologyPreparationPrevalencePrimary Senile Degenerative DementiaPsychiatryPublic HealthResearchResearch PersonnelResearchersRespiration CalorimetryRiskRoleSmall Molecular Weight RNASmall Nuclear RNATauopathiesTechniquesTestingTherapeutic InterventionThesaurismosisTrainingUniversitiesWritingabnormal tauaccelerated agingaccelerated biological ageaccelerated biological agingage accelerationagesaging associated diseaseaging associated disordersaging related diseaseaging related disordersalcohol abuse therapyalcohol abuse treatmentalcohol effectalcohol exposedalcohol exposurealcohol ingestionalcohol intakealcohol metabolismalcohol misusealcohol product usealcohol treatmentalcohol usealcohol use disorderalcoholic beverage consumptionalcoholic drink intakealdehyde dehydrogenasesalzheimer modelalzheimer riskassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingastrocytic gliabusiness-friendly environmentcareercaspase 14cell typechronic EtOH drinkingchronic alcohol consumptionchronic alcohol drinkingchronic alcohol ingestionchronic alcohol usechronic ethanol consumptionchronic ethanol drinkingchronic ethanol ingestioncognitive defectscognitive functioncollaborative atmospherecollaborative environmentdesigndesigningdevelopmentaldisease associated with agingdisease of agingdisorder of agingdisorders associated with agingdisorders related to agingepidemiologicepidemiologicalepigeneticallyepigenomeepigenomicsethanol consumptionethanol drinkingethanol effectethanol exposedethanol exposureethanol ingestionethanol intakeethanol misuseethanol product useethanol useethanol use disorderexposed to alcoholexposed to ethanolexposure to alcoholexposure to ethanolgenome mutationhippocampalhomesinnovateinnovationinnovativeinteractive atmosphereinteractive environmentinterdisciplinary approachinterdisciplinary atmosphereinterdisciplinary environmentintervention therapyion trap mass spectrometryknockin micemalemalleable riskmass fragmentometrymetabolic phenotypemetabolism disordermetabolomemetabonomemetabotypemicrotubule associated protein tau mutationmicrotubule bound taumicrotubule-associated protein tau mutationmicrotubule-bound taumini-ICEmitochondrialmodifiable riskmolecular profilemolecular signaturemouse modelmultidisciplinary approachmultiomicsmultiple omicsmurine modelmutantmutant taumutation in microtubule associated protein taumutation in microtubule-associated protein tauneuron developmentneuronalneuronal developmentneuropathologicneuropathologic tauneuropathologicalneuropathological tauneuropathologynew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachoxidationpanomicspathogenic taupathogenic tau gene mutationpathological change in taupathophysiologypathwaypeer-group atmospherepeer-group environmentpharmacologicpre-clinical studypreclinical studypreparationsprimary degenerative dementiarespiratoryresponserisk mitigationsenile dementia of the Alzheimer typesexskillssnRNAsocial roletautau Proteinstau abnormalitytau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau induced degenerationtau induced neurodegenerationtau intronic mutationtau mediated neurodegenerationtau mutationtau neurodegenerative diseasetau neuropathologytau pathological changetau pathologytau pathophysiologytau proteinopathytau related neurodegenerationtau-induced pathologytauopathic neurodegenerative disordertauopathytraittranscriptomicsuRNAunhealthy alcohol usevaporτ Proteinsτ mutation♀♂
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PROJECT SUMMARY / ABSTRACT
Epidemiological projections indicate a substantial rise in Alzheimer's disease (AD) cases, reaching an
estimated 152 million by 2050. Among the multifaceted factors influencing AD progression, chronic alcohol
consumption is implicated as a modifiable risk factor for AD. My long-term goal is to uncover mechanisms that…
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