grant

Alcohol, Gut derived inflammation, Disturbed Tryptophan Metabolism and CVD risk in People With HIV (GUT CVD HIV)

Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 11 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025AIDS VirusASCVDAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAgingAlcohol Chemical ClassAlcohol DrinkingAlcohol consumptionAlcoholic beverage heavy drinkerAlcoholsAnabolismAncillary StudyAtherosclerosisAtherosclerotic Cardiovascular DiseaseBehavioralBiogenesisBiological MarkersCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCardiac infarctionCardiovascular DiseasesCatabolismCohort StudiesConcurrent StudiesDataDeath RateDevelopmentDisease ProgressionDouble-Blind MethodDouble-Blind StudyDouble-BlindedDouble-Masked MethodDouble-Masked StudyEtOH drinkingEtOH useEventFundingGenerationsGut Epithelial PermeabilityGut HyperpermeabilityGut permeabilityHIVHIV InfectionsHIV-1HIV-IHIV1HTLV-III InfectionsHTLV-III-LAV InfectionsHeartHeart failureHeavy DrinkerHeavy DrinkingHistoryHuman Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsHuman immunodeficiency virus 1ImmuneImmune Cell ActivationImmunesIncidenceInfectionInflammationInflammatoryIntestinal Epithelial PermeabilityIntestinal HyperpermeabilityIntestinal permeabilityKynurenineL-TryptophanLAV-HTLV-IIILevotryptophanLymphadenopathy-Associated VirusMeasuresMediatingMorbidityMorbidity - disease rateMyocardial InfarctMyocardial InfarctionNIAAANational Institute on Alcohol Abuse and AlcoholismOrigin of LifePathogenesisPathogenicityPathway interactionsPeripheralPersonsPhenotypePlacebosPlayProbioticsProcessRecording of previous eventsResearchRiskRisk FactorsRoleSham TreatmentT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT4 CellsT4 LymphocytesTestingTherapeuticTryptophanTryptophan MetabolismTryptophan Metabolism PathwayVeteransViremiaVirus-HIVWorkalcohol effectalcohol ingestionalcohol intakealcohol product usealcohol usealcoholic beverage consumptionalcoholic drink intakearmatheromatosisatherosclerotic diseaseatherosclerotic vascular diseasebio-markersbiologic markerbiomarkerbiosynthesiscardiac failurecardiac infarctcardiovascular disease riskcardiovascular disordercardiovascular disorder riskcardiovascular riskcardiovascular risk factorcohortcoronary attackcoronary infarctcoronary infarctiondeath riskdevelopmentaldrink heavilydysbacteriosisdysbiosisdysbioticefficacy testingethanol consumptionethanol drinkingethanol effectethanol ingestionethanol intakeethanol product useethanol useexcessive alcohol consumptionexcessive alcohol ingestionexcessive alcohol intakeexcessive drinkingexcessive ethanol ingestionextreme drinkinggut dysbiosisheart attackheart infarctheart infarctionheavy alcohol usehistoriesimmune activationimprovedmicrobialmicrobial imbalancemicrobiomemortalitymortality ratemortality ratiomortality riskpathwayprospectiverandomized, clinical trialssenescencesenescentsham therapysocial rolesystemic inflammationsystemic inflammatory responsethymus derived lymphocytevascular inflammationviraemiaviral sepsisvirusemia
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People living with HIV (PWH) have elevated risks of cardiovascular disease (CVD) ranging from myocardial
infarction to heart failure. Heavy alcohol use is a significant cardiovascular risk factor and is common among
PWH. Since, heavy alcohol drinking and HIV-1 infection are independently associated with the increased risk
of CVD, their interactive…

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Alcohol, Gut derived inflammation, Disturbed Tryptophan Metabolism and CVD risk in People With HIV (GUT CVD HIV) — VANDE | Dev Procure