grant
Airway Innate Immune Responses to Coccidioides Infection
Organization UNIVERSITY OF ARIZONALocation TUCSON, UNITED STATESPosted 28 Jul 2025Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025AcuteAffectAirAmericasAnimalsAntifungal TherapyAreaAscomycetesAscomycotaAssayBioassayBiological AssayBiologyCD49b-CD29Central AmericaCessation of lifeCharacteristicsChillsChronicCoccidioidesCoccidioidomycosisContainmentDeathDeath RateDefense MechanismsDesert rheumatismDevelopmentDiagnosisDiseaseDisorderDistantDoseEncapsulatedEpitheliumExhibitsFatal OutcomeFoundationsFungal SporesFungus DiseasesFutureGene ExpressionGenesGlycoprotein Ia-IIaGoalsHealthHealth Care SystemsHematopoieticHumanImmuneImmune reactionImmune systemImmunesImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunologyImmunosuppressed HostIn VitroIndividualInfectionInflammationInflammatoryInflammatory ResponseInhalationInhalingInnate Immune ResponseInnate ImmunityIntegrin alpha2beta1Knock-outKnockoutKnowledgeLife CycleLife Cycle StagesLungLung Respiratory SystemLung infectionsMediatingMexicoModelingModern ManMolecularMycologyMycosesNative ImmunityNatural ImmunityNon-Specific ImmunityNonspecific ImmunityOrganPaintPathogenicityPathway interactionsPersonsPlatelet Membrane Glycoprotein Heterodimer Ia-IIaPlayPopulationPositionPositioning AttributePredispositionProductionProtein EngineeringProteinsPublic HealthRecombinantsReportingResearchResearch ResourcesResourcesRespiratory EpitheliumRiskRoleRouteSan Joaquin Valley feverSeverity of illnessSoilSouth AmericaSouthwest U.S.Southwest USSouthwestern United StatesSpleenSpleen Reticuloendothelial SystemStructureStructure of respiratory epitheliumSusceptibilitySymptomsTestingThe science of MycologyTherapeutic FungicidesVLA-2Valley FeverVery Late Antigen-2airway epitheliumairway injuryalpha2beta1Integrinanti-fungalanti-fungal agentsanti-fungal druganti-microbialantimicrobialarid areasarid landarid regiondesert feverdevelopmentaldisease severityexperienceexperimentexperimental researchexperimental studyexperimentsextracellularextracellular vesiclesfightingflufungal infectionfungal infectious disease treatmentfungal pathogenfungi pathogenfungusfungus infectiongenetic protein engineeringhemopoieticimmunoreactionimmunosuppressed patientimpaired airwayinjured airwayinnovateinnovationinnovativelife coursemortality ratemortality ratiomouse modelmultidisciplinarymurine modelnovelpathogenpathogenic funguspathwayposttranscriptionalprotein designpsychological defense mechanismpublic health relevancepulmonarypulmonary infectionsrespiratory injuryrespiratory tract epitheliumrespiratory tract injuryresponsesac fungiskillssocial roletherapeutic agent developmenttherapeutic development
Description preview
Coccidioidomycosis, also known as Valley Fever, is a serious fungal infection caused by the Coccidioides
species. These dimorphic fungi thrive in the arid regions of the Americas, including the southwestern United
States, Mexico, and certain parts of Central and South America. Recently, there has been a substantial rise in
Coccidioidomycosis…
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