grant
Aging trajectories and outcomes of older adults with acute myeloid leukemia
Organization UNIVERSITY OF NEBRASKA MEDICAL CENTERLocation OMAHA, UNITED STATESPosted 12 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY202521+ years oldAML - Acute Myeloid LeukemiaActivities of Daily LivingActivities of everyday lifeAcute Myeloblastic LeukemiaAcute Myelocytic LeukemiaAcute Myelogenous LeukemiaAdultAdult HumanAfter CareAfter-TreatmentAftercareAgeAgingAttentionAuditoryB-Cell CLL/lymphoma 2B-cell lymphoma protein 2BCL-2 ProteinBCL2 proteinBrainBrain Nervous SystemCancer TreatmentCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive agingCognitive declineCognitive function abnormalDataDecision MakingDiagnosisDiseaseDisease remissionDisorderDisturbance in cognitionDorsalEEGEORTCEducationEducational aspectsElectroencephalogramElectroencephalographyEncephalonEnrollmentEuropean Organization for Research and Treatment of CancerEventExerciseGoalsHematologic CancerHematologic MalignanciesHematologic NeoplasmsHematological MalignanciesHematological NeoplasmsHematological TumorHematopoietic CancerIADLImmediate MemoryImpaired cognitionImpairmentInterdisciplinary ResearchInterdisciplinary StudyKnowledgeLong-term cohort studyLongitudinal cohort studyMalignant Hematologic NeoplasmMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMeasuresMethodsMultidisciplinary CollaborationMultidisciplinary ResearchNeuropsychologic TestsNeuropsychological TestsNeurosciencesNewly DiagnosedOncologistOutcomeParticipantPatientsPhysical FunctionQOLQuality of lifeQuestionnairesRecommendationRemissionResearchRiskRisk FactorsScientistShort-Term MemoryTimeVisualacute granulocytic leukemiaacute myeloid leukemiaadulthoodagesanti-cancer therapyattentional controlcancer therapycancer-directed therapychemotherapyco-morbidco-morbiditycognitive dysfunctioncognitive functioncognitive losscognitive processcognitive reservecomorbiditycompare to controlcomparison controldaily living functiondaily living functionalitydecline in functiondecline in functional statusdistractionenrollexecutive controlexecutive functionfrailtyfunctional abilityfunctional capacityfunctional declinefunctional improvementfunctional independencefunctional status declinehealth related quality of lifeimprove functionimprovedimproved functional outcomesinsightinstrumental activity of daily livingleukemialeukemia treatmentleukemic therapymultimorbiditymultiple chronic conditionsneuroprotectionneuroprotectivenew approachesnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel approachesnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approacholder adultolder adulthoodphysical impairmentpost treatmentsexshared decision makingsuccessworking memory
Description preview
PROJECT SUMMARY
In the US, over one-third of older adults ≥60 years with acute myeloid leukemia (AML) die without receiving any
chemotherapy, primarily due to concerns of cognitive decline and loss of functional independence if they chose
to undergo intensive chemotherapy. A combination of venetoclax and low-intensity chemotherapy offers an…
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