🗂️
Archived grant — no longer open
This grant has closed and is kept as a historical reference. Browse current grants for active opportunities.
grant
Aging dependent transformation of oligodendrocyte precursor cells
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 15 Apr 2021Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY20252-photonAblationAddressAgeAgingAmyotrophic Lateral SclerosisAmyotrophic Lateral Sclerosis Motor Neuron DiseaseAnimalsAntigen Presentation PathwayAntigen Processing and PresentationAntigensAstrocytesAstrocytusAstrogliaAutophagocytosisAutoregulationBackBehaviorBody TissuesBrainBrain DiseasesBrain DisordersBrain Nervous SystemBrain TraumaBrain regionCSPG4CSPG4 geneCalciumCalcium Ion SignalingCalcium SignalingCell AgingCell BodyCell Communication and SignalingCell FunctionCell LocomotionCell MigrationCell MovementCell PhysiologyCell ProcessCell SenescenceCell SignalingCell divisionCell-Extracellular MatrixCellsCellular AgingCellular FunctionCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessCellular SenescenceCharacteristicsChondroitin 4 SulfateChondroitin Sulfate ACicatrixClass I GenesComplexComputational BiologyDNA Damage RepairDNA Molecular BiologyDNA RepairData SetDevelopmentDiseaseDisorderDisseminated SclerosisDorsumECMEncephalonEncephalon DiseasesEnvironmentExhibitsExposure toExpression ProfilingExtracellular MatrixFilopodiaGehrig's DiseaseGene TranscriptionGenerationsGenetic TranscriptionGliaGlial CellsGrowth AgentsGrowth FactorGrowth SubstancesHeterogeneityHomeostasisHortega cellImageImmuneImmunesInflammationInflammatoryInjuryIntracellular Communication and SignalingIntracranial CNS DisordersIntracranial Central Nervous System DisordersIonsKO miceKnock-out MiceKnockout MiceKnowledgeKolliker's reticulumLearningLevarterenolLevonorepinephrineLifeLou Gehrig DiseaseMCSPGMEL-CSPGMHC Class IMHC Class I GenesMHC antigenMSK16MetabolicMethodologyMiceMice MammalsMicrogliaMolecularMolecular BiologyMonitorMotilityMsecMultiple SclerosisMurineMusMyelinMyelin SheathNG2Natural regenerationNerve CellsNerve Impulse TransmissionNerve TransmissionNerve Transmitter SubstancesNerve UnitNervous SystemNeural CellNeurocyteNeurogliaNeuroglial CellsNeurologic Body SystemNeurologic Organ SystemNeuronal TransmissionNeuronsNeurotransmittersNon-neuronal cellNonneuronal cellNoradrenalineNorepinephrineNull MouseOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellOrganPatternPhenotypePhysiologicPhysiologicalPhysiological HomeostasisPhysiologyPlayPopulationPopulation DynamicsPopulation HeterogeneityProcessProductionProliferatingPropertyProteins Growth FactorsProteoglycanRNA ExpressionRadialRadiusRegenerationRejuvenationReplicative SenescenceRoleScarsSignal TransductionSignal Transduction SystemsSignalingSiteSubcellular ProcessSynapsesSynapticTestingTherapeuticTimeTissuesTranscriptionTransgenic MiceTraumatic Brain InjuryUnscheduled DNA Synthesisadult youthage associated alterationsage associated changesage associated effectsage correlated alterationsage correlated changesage dependent alterationsage dependent changesage effectage induced alterationsage induced changesage related alterationsage related changesage related effectsage specific alterationsage specific changesaged brainagesaging associated alterationsaging associated changesaging brainaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging effectaging induced alterationsaging induced changesaging related alterationsaging related changesaging specific alterationsaging specific changesalterations with ageastrocytic gliaautophagyaxon signalingaxon-glial signalingaxonal signalingbiological signal transductioncell behaviorcell motilitycell typecellular behaviorchanges with agecomputer biologyconditional knock-outconditional knockoutcytokinedensitydesigndesigningdevelopmentaldiverse populationsenvironmental changeexperiencegitter cellglia signalingglial neural stem cellglial progenitorglial signalingglial stem cellgray matterheterogeneous populationimagingimaging in vivoimaging studyimmunogenimpact of agein vivoin vivo imaginginfluence of ageinjuriesinnovateinnovationinnovativeinsightinsular sclerosislocomotor learningmesogliamicroglial cellmicrogliocytemigrationmillisecondmotor learningmyelinationnerve cementnerve signalingneural circuitneural circuitryneural signalingneurocircuitryneuroglial progenitorneuroglial stem cellsneuron glial antigen 2neuronalneuronal signalingneurotransmissionnew approachesnovelnovel approachesnovel strategiesnovel strategyoligodendrocyte precursoroligodendrocyte precursor celloligodendrocyte progenitoroligodendrocyte stem cellperivascular glial cellpopulation diversitypreservationpro-agingprogenitorprogeronicpromote agingregenerateregeneration potentialregenerative potentialrejuvenating interventionrejuvenation approachrejuvenation strategiesrejuvenation therapyrejuvenation treatmentrepairrepairedreplicative agingresponsescRNA sequencingscRNA-seqself renewing cellsenescencesenescentsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestemsubstantia albasubstantia griseasynapsesynaptic circuitsynaptic circuitrytherapeutic rejuvenationtooltraumatic brain damagetwo-photonwhite matteryoung adultyoung adult ageyoung adulthoodyounger age
Applications closed.
Description preview
Summary:
To sustain neural signaling and enable plasticity throughout life, the nervous system relies on homeostatic
interactions with a diverse population of glial cells, which create and modify the extracellular matrix, remove
ions and neurotransmitters, provide metabolic support and promote functional reorganization of circuits in
response to…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click