grant
Aging-associated changes in the brain's response after a cardiac arrest
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 15 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY202521+ years oldAcquired brain injuryAcuteAddressAdultAdult HumanAgeAgingAmmon HornAnimal ModelAnimal Models and Related StudiesAnimalsApoptosis-Related Cysteine Protease Caspase 1AsystoleAttenuatedAwardBasic ResearchBasic ScienceBehavior assessmentBehavioralBiochemicalBiology of AgingBrainBrain DiseasesBrain DisordersBrain InflammationBrain InjuriesBrain IschemiaBrain Nervous SystemCASP-1CASP1CASP1 geneCardiac ArrestCardiopulmonary ResuscitationCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCaringCaspase-1Caspase-1 GeneCell BodyCell DeathCellsCellular injuryCerebral IschemiaClinical ManagementCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalComplementComplement ProteinsComplexCornu AmmonisCritical CareDataDisturbance in cognitionDoctor of PhilosophyDysfunctionElderlyElectrophysiologyElectrophysiology (science)EncephalitisEncephalonEncephalon DiseasesEnvironmentEvaluationExhibitsExperimental DesignsFunctional disorderFundingGoalsHeart ArrestHippocampusHistologicHistologicallyHortega cellICE ProteaseIL-1 beta ConvertaseIL-1 beta-Converting EnzymeIL-1BCIL-1b Converting EnzymeIL1B-ConvertaseIL1BCIL1BCEImpaired cognitionImpairmentIncidenceIndividualInflammagingInflammasomeInflammationInjuryIntensive Care UnitsInterleukin 1-B Converting EnzymeInterleukin 1-Beta ConvertaseInterleukin-1 Beta Converting EnzymeInterleukin-1 Converting EnzymeIntracranial CNS DisordersIntracranial Central Nervous System DisordersInvestigatorsIschemiaIschemic Brain InjuryIschemic EncephalopathyK-AwardsK-Series Research Career ProgramsKnowledgeLinkMacromolecular Protein ComplexesMeasurementMeasuresMediatingMediatorMemoryMemory DeficitMemory impairmentMentorsMentorshipMiceMice MammalsMicrogliaModelingMolecularMultiprotein ComplexesMurineMusNerve DegenerationNervous System PhysiologyNeurologicNeurologic functionNeurologic outcomeNeurologicalNeurological functionNeurological outcomeNeuron DegenerationNeuronal InjuryNeurophysiology / ElectrophysiologyOlder PopulationPathway interactionsPatientsPh.D.PhDPhysiciansPhysiopathologyPlayProceduresProcessPrognosisProteinsResearchResearch Career ProgramResearch PersonnelResearch TrainingResearchersRoleScientistStructureSurvivorsSynapsesSynapticSynaptic plasticityTestingTherapeutic AgentsTimeTranslational ResearchTranslational ScienceTranslationsUnited Statesabnormal brain functionadult animaladult youthadulthoodadvanced ageage associatedage associated alterationsage associated changesage associated differenceage associated neurodegenerationage associated neurodegenerative diseaseage associated neurodegenerative disorderage based differenceage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage dependent differenceage dependent neurodegenerationage dependent neurodegenerative conditionage dependent neurodegenerative diseaseage dependent neurodegenerative disorderage dependent variationage differenceage induced alterationsage induced changesage linkedage relatedage related alterationsage related changesage related differenceage related neurodegenerationage related variationage specificage specific alterationsage specific changesage specific differenceage-driven neurodegenerative disordersage-related inflammationage-related neurodegenerative diseaseage-related neurodegenerative disorderagedaged animalaged animalsaged brainaged miceaged mouseagesaging associated alterationsaging associated changesaging associated inflammationaging associated neurodegenerationaging associated neurodegenerative diseaseaging brainaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging processaging related alterationsaging related changesaging related neurodegenerationaging related neurodegenerative diseaseaging related neurodegenerative disorderaging specific alterationsaging specific changesalterations with ageanimal old ageattenuateattenuatesbehavioral assessmentbrain damagebrain dysfunctionbrain impairmentbrain injury responsebrain-injuredcardiac resuscitationcell damagecell injurycellular damagecerebral ischemic damagecerebral ischemic injurychanges with agecognitive defectscognitive dysfunctioncognitive losscomplementationdamage to cellsdiffer by agedifference across agedifference in agedysfunctional brainelderly animalelderly miceelectrophysiologicalexperiencegeriatricgitter cellglial activationglial cell activationheart resuscitationhippocampalimprovedinflamm-ageinginflamm-aginginflammation associated with aginginjuriesinjury to cellsischemic brain damagemature animalmemory dysfunctionmesogliamicroglial cellmicrogliocytemodel of animalmouse modelmurine modelnecrocytosisnerve cell deathnerve cell lossnervous system functionneural degenerationneural inflammationneurodegenerationneurodegenerativeneuroinflammationneuroinflammatoryneurological degenerationneuron cell deathneuron cell lossneuron deathneuron injuryneuron lossneuronal cell deathneuronal cell lossneuronal deathneuronal degenerationneuronal lossnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachold animalsold miceolder groupsolder individualsolder personpathophysiologypathwayperivascular glial cellpharmacologicresponseresponse to brain injurysenior citizenskillssocial rolesynapsesynapse functionsynaptic functiontranslationtranslation researchtranslational investigationvariation by ageyoung adultyoung adult ageyoung adulthoodyounger age
Description preview
Project Summary/Abstract
The goal of this Mentored Career Development Award is to facilitate the primary investigator's transition to
independence as a physician-scientist studying the molecular mechanisms underlying brain injury that occurs
after a cardiac arrest. The candidate is a MD/PhD critical care physician and anesthesiologist with a…
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