grant

Advancing targeted delivery of intracellular protein therapeutics

Organization BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)Location BOSTON, UNITED STATESPosted 5 Mar 2026Deadline 31 Dec 2030
NIHUS FederalResearch GrantFY2026AddressAdvanced DevelopmentBehaviorBiocompatible MaterialsBiogenesisBiologic FactorBiologicalBiological FactorsBiomaterialsCell BodyCellsCirculationComplexCytosolDrug DeliveryDrug Delivery SystemsEncapsulatedEnvironmentGeneticGenetic MaterialsGoalsHost FactorHost Factor ProteinIntegration Host FactorsInvestigatorsLaboratoriesModalityOrigin of LifeOutcomePerformanceProductionPropertyProtein EngineeringProteinsResearchResearch PersonnelResearchersRetroviridaeRetrovirusesRoleSerum ProteinsSignal PathwayTherapeuticTropismViralViral GeneticsViral GenomeViral Structural ProteinsVirus AssemblyVirus-RetrovirusVirus-like particleWorkbiologicbiological materialcellular targetingclinical applicabilityclinical applicationclinical translationclinically translatabledesigndesigninggenetic protein engineeringgenome editinggenomic editingheuristicsimprovedin vivomacromoleculenano medicinalnano medicinenano particlenano-sized particlenanomedicinalnanomedicinenanoparticlenanoparticle drugnanosized particlenative protein drugnext generationpharmaceutical proteinprotein designprotein drug agentprotein-based drugsite targeted deliverysocial roletargeted deliverytherapeutic outcometherapeutic proteintherapy outcometooluptakeviral assemblyvirus geneticsvirus genomevirus-like nanoparticlesviruslike particle
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PROJECT SUMMARY
Intracellular protein delivery has immense potential for research and therapeutic applications, from replacing

dysfunctional proteins to modulating key signaling pathways and safely delivering genome editing modalities.

However, efficiently delivering functional proteins into the cell cytosol remains a significant challenge.…

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Advancing targeted delivery of intracellular protein therapeutics — BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) | UNITED ST | Dev Procure