grant
Advancing Pregnenolone as a Novel Therapy for Co-Occurring Cannabis Use Disorder and Depression
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 15 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY202621+ years oldAbsence of pain sensationAbsence of sensibility to painAdultAdult HumanAdverse ExperienceAdverse effectsAdverse eventAlcohol DrinkingAlcohol consumptionAllopregnanoloneAmericanAnimal Experimental UseAnimal ExperimentationAnimal ModelAnimal Models and Related StudiesAnimal ResearchAnochlesiaAnxietyAppetite stimulatedAreaAttenuatedBipolar Affective PsychosisBipolar DepressionBipolar DisorderBlood SerumBrainBrain Nervous SystemBrain regionCB1CB1 ReceptorCB1RCNR1 geneCannabinoid Receptor CB1CannabinoidsCannabisCatalepsyCell Communication and SignalingCell SignalingClinicalClinical TreatmentClinical TrialsCognitionCognitiveDataDoseDrug KineticsDrug TherapyEmotional DepressionEncephalonEnrollmentEtOH drinkingEtOH useExhibitsFDA approvedFeasibility StudiesFeels no painFrequenciesFunctional impairmentHalf-LifeHourHumanHypothermiaIRBIRBsIncreased food appetiteIndividualInstitutional Review BoardsIntoxicationIntracellular Communication and SignalingIntravenousLinkLocomotionMajor Depressive DisorderManic-Depressive PsychosisMedical MarijuanaMedicinal MarijuanaMemoryMental DepressionModern ManMoodsNo sensitivity to painOral AdministrationOral Drug AdministrationPersonsPharmacokineticsPharmacological TreatmentPharmacotherapyPhasePlacebosPopulationPositionPositioning AttributePost-Natal DepressionPost-Partum DepressionPostnatal DepressionPostpartum DepressionPreclinical dataPregnenolonePrevalenceProceduresProcessPropertyProtocolProtocols documentationPsychological reinforcementPsychosesPublic HealthReceptor ProteinRegulatory approvalReinforcementRelapseReportingResearchRestRewardsRiskSerumSeveritiesSham TreatmentSignal TransductionSignal Transduction SystemsSignalingSiteSleepSubstance Use DisorderSymptomsTHC co-useTHC useTetrahydrocannabinol co-useTetrahydrocannabinol useTherapeuticTranslatingTreatment outcomeWithdrawal SymptomWomanWorkaddictionaddictive disorderadulthoodalcohol ingestionalcohol intakealcohol product usealcohol usealcohol use disorderalcoholic beverage consumptionalcoholic drink intakeanalgesiaanimal experimentationsantagonismantagonistanxiety symptomsanxious symptomattenuateattenuatesbiological signal transductionbipolar affective disorderbipolar depressedbipolar diseasebipolar illnessbipolar mood disordercannabinoid receptor 1cannabinoid receptor type 1cannabinoid type 1cannabis cravingcannabis usecannabis use disordercannabis withdrawalclinical depressionclinical interventionclinical relevanceclinical therapyclinically relevantco-morbidco-morbid depressionco-morbid with depressionco-morbidityco-morbidity with depressionco-occurring disorderscommon treatmentcomorbid depressioncomorbid with depressioncomorbiditycomorbidity with depressioncostcue reactivitydepressiondepression co-morbiditydepression comorbiditydepression symptomdepressivedepressive symptomsdevelop therapydrug interventiondrug treatmentdual diagnosiseCB systemearly onseteffective therapyeffective treatmentefficacy studyefficacy trialendocannabinoid systemendogenous cannabinoid systemenrollethanol consumptionethanol drinkingethanol ingestionethanol intakeethanol product useethanol useethanol use disorderexperiencefeasibility trialimprovedincreased appetiteincreased hungerinhibitorintervention developmentintraoral drug deliverymajor depressionmajor depression disordermanic depressive disordermanic depressive illnessmarijuana cravingmarijuana usemarijuana use and disordermarijuana use disordermedical cannabismedicinal cannabismodel of animalmood regulationnatural hypothermianeuroactive steroidsneurosteroidsnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsplacebo control trialplacebo controlled trialpre-clinical researchpreclinical findingspreclinical informationpreclinical researchreceptorreduced alcohol useregulatory authorizationregulatory certificationregulatory clearanceresponsesafety and feasibilitysham therapyside effectsubstance use and disordertherapeutic cannabistherapeutic marijuanatherapy developmenttreatment developmenttrial regimentrial treatment
Description preview
Abstract
Cannabis use and cannabis use disorder (CUD) are increasing in prevalence. When present, CUD exhibits
relapse rates similar to those of other substance use disorders, making it a significant and growing public
health concern. Notably, CUD is highly comorbid with depression. People with CUD are up to four times more
likely to experience…
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