grant
Advanced body composition imaging to improve outcomes in lung transplantation
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 25 Aug 2025Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY2025AbdomenAbdominal obesityAddressAdipose tissueAndroid fat distributionBMIBMI percentileBMI z-scoreBilateralBody CompositionBody mass indexCAT scanCT X RayCT XrayCT imagingCT scanCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCentral obesityCentripetal obesityCessation of lifeClinicalCognitive DiscriminationCohort StudiesComputed TomographyComputer softwareConcurrent StudiesDataDeathDecision MakingDiscriminationEnrollmentEnsureEvaluationFatty TissueGeneral PopulationGeneral PublicGeneral RadiologyGuidelinesHeart VascularImageInfrastructureKnowledgeLungLung DiseasesLung GraftingLung Respiratory SystemLung TransplantationLung damageMalignant Tumor of the LungMalignant neoplasm of lungMeasuresModelingMorbidityMorbidity - disease rateNHLBINational Heart, Lung, and Blood InstituteObesityOrganOutcomePatientsPerformancePerioperativeProviderPulmonary CancerPulmonary DiseasesPulmonary DisorderPulmonary GraftPulmonary TransplantPulmonary TransplantationPulmonary malignant NeoplasmQuetelet indexRadiologyRadiology SpecialtyRecommendationRiskRisk AssessmentRisk FactorsScanningSoftwareSolidSpecific qualifier valueSpecifiedSurgical complicationTomodensitometryTransplantationTruncal obesityWaiting ListsWorkX-Ray CAT ScanX-Ray Computed TomographyX-Ray Computerized TomographyXray CAT scanXray Computed TomographyXray computerized tomographyabdominal CTabdominal computed tomographyadiposeadipositycandidate identificationcandidate selectioncatscanchest CTchest computed tomographycirculatory systemclinical practicecohortcomputed axial tomographycomputer tomographycomputerized axial tomographycomputerized tomographycorpulencedatabase expansiondeath riskdisease of the lungdisorder of the lungenrollgraft dysfunctionhigh riskimagingimprovedimproved outcomeinnovateinnovationinnovativeinterestlung cancerlung disorderlung injurylung transplantmortalitymortality risknon-contrast CTnoncontrast CTnoncontrast computed tomographypost-transplantpost-transplantationposttransplantposttransplantationprospectivepulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injuryrisk minimizationrisk stratificationscreeningscreeningsstatisticsstratify risksubcutaneoussubdermalsurgery complicationtooltransplantvisceral obesitywaitlistwhite adipose tissueyellow adipose tissue
Description preview
PROJECT SUMMARY
Median survival after lung transplantation (Tx) is only 6.7 years, compared to >11 years after other solid organ
Tx. Obesity increases risk of death on the Tx waitlist, early severe lung injury (primary graft dysfunction, PGD),
and death after lung Tx. We have repeatedly shown that measures of adipose distribution on computed…
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