grant
Adipocyte-Eosinophil Communication and Its Role in Regulation of Airway Function
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 17 Jun 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025AddressAdipocytesAdipose CellAdipose tissueAgonistAirway Hyper-responsivenessAllergic ReactionAllergic inflammationAsthmaAutoregulationBlood EosinophilBody TissuesBronchial AsthmaBronchial ConstrictionBronchoconstrictionCCL11CCL11 geneCITE sequencingCITE-seqCITEseqCellular Indexing of Transcriptomes and Epitopes by SequencingCo-cultureCocultivationCocultureCoculture TechniquesCommunicationCompensatory HyperinsulinemiaDataDevelopmentDiabetes MellitusDiseaseDisorderEndocrine Gland SecretionEnergy ExpenditureEnergy MetabolismEosinophilic GranulocyteEosinophilic LeukocyteEpidemicFGF-21FGF21FGF21 geneFat CellsFatsFatty TissueFatty acid glycerol estersGLP-1GLP-1 receptorGLP-I receptorGenetic ModelsGlp-1GoalsHealthHealth Care SystemsHomeostasisHormonesHouse Dust MitesHousedust MitesHumulin RHyperinsulinemiaHyperinsulinismImmune responseImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsInflammationInsulinInsulin ResistanceKnowledgeLeannessLipocytesLipolysisLiteratureLungLung InflammationLung ParenchymaLung Respiratory SystemLung TissueMGC22554MacrophageMarrow EosinophilMature LipocyteMature fat cellMediatingMediatorMetabolicMiceMice MammalsModernizationMurineMusMφNatureNerveNon obeseNonobeseNovolin RObese MiceObesityOregonOrganPhenotypePhysiological HomeostasisPlayPneumonitisPrevalencePulmonary InflammationPyroglyphidaeReflexReflex actionRegular InsulinRegulationResearchRoleSCYA11ScienceStructure of parenchyma of lungSystems BiologyTestingTherapeutic HormoneTherapeutic InterventionThinkingThinnessTissuesUniversitiesVisceraladipocytokinesadipokinesadiposeadiposityairway epithelium inflammationairway hyper-reactivityairway hyperactivityairway hyperreactivityairway hyperresponsivenessairway hypersensitivityairway inflammationallergen responseallergic airway epithelium inflammationallergic airway inflammationallergic responseallergy responseasthma modelasthma patientasthmaticasthmatic patientcellular indexing of transcriptomes and epitopes by single cell sequencingco-morbidco-morbiditycombatcomorbiditycorpulencedevelopmentaldiabeteseosinophilfibroblast growth factor 21glucagon-like peptide 1glucagon-like peptide-1 receptorglucose tolerancehost responseimmune system responseimmunoresponseinnovateinnovationinnovativeinsulin resistantinsulin sensitivityinsulin toleranceintervention therapymouse modelmurine modelnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachob/ob mouseobese asthmaobese individualsobese peopleobese personobese populationobese subjectsobesity interventionobesity preventionobesity therapyobesity treatmentobesity-associated asthmaobesity-related asthmaprevent obesityrecruitrespiratory inflammationrespiratory tract inflammationresponsesocial roletherapeutic agent developmenttherapeutic developmenttherapeutically effectivethoughtswhite adipose tissueyellow adipose tissue
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PROJECT SUMMARY
The concurrent rise in the prevalence of asthma and obesity poses a significant burden on health care system.
Obesity accompanied by loss of insulin sensitivity and compensatory hyperinsulinemia drives severe
inflammation and is a defining feature of poorly controlled asthma endotype. While we recognize that obesity
exacerbates and…
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