grant
Addressing Vulnerabilities to the Maintenance of Transplantation Tolerance
Organization UNIVERSITY OF CHICAGOLocation CHICAGO, UNITED STATESPosted 17 Jul 2012Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2025AddressAffinityAlloantigenAnimalsAntigensAvidityBasal Transcription FactorBasal transcription factor genesCD154CD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD40LCD40LGCardiac TransplantationCell BodyCell Communication and SignalingCell SignalingCellsCharacteristicsChronicClass II GenesClone CellsDataDown-RegulationDysfunctionEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExposure toFunctional disorderGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenetic TranscriptionGraft RejectionHLA Class II GenesHeart GraftingHeart TransplantationHeterogeneityImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIndividualInfectionInflammationInflammatoryIntracellular Communication and SignalingL monocytogenesL. monocytogenesLigandsListeria monocytogenesMHC Class IIMHC Class II GenesMaintenanceMediatingMiceMice MammalsModelingMolecularMolecular FingerprintingMolecular ProfilingMurineMusPathway interactionsPeptide-MHCPeptide-Major Histocompatibility Protein ComplexPeptide/MHC ComplexPhysiopathologyPopulationPredispositionQOL improvementRNA ExpressionRegulatory T-LymphocyteResistanceRestRoleSignal TransductionSignal Transduction SystemsSignalingSpecificitySplenocyteSusceptibilitySystemic infectionT memory cellT-CellsT-LymphocyteT4 CellsT4 LymphocytesTNFSF5TNFSF5 geneTRAP GeneTestingTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransplant RecipientsTransplant RejectionTransplantationTransplantation RejectionTransplantation ToleranceTreganergybiological signal transductioncardiac graftcell fixingcytokinedensitydesigndesigningepigeneticallyexhaustionheart transplantimmune suppressionimmune suppressive activityimmune suppressive functionimmunogenimmunosuppressedimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovements in QOLimprovements in quality of lifeloss of functionmemory T lymphocytemolecular profilemolecular signaturemouse modelmurine modelpMHCpathophysiologypathwaypatient tolerabilitypatient tolerancepeptide Ipost-transplantpost-transplantationposttransplantposttransplantationpreventpreventingprogramsquality of life improvementregulatory T-cellsresistantsocial rolethymus derived lymphocytetranscription factortransplanttransplant patient
Description preview
Project 1 Summary
Transplantation tolerance bears the potential to improve the quality of life of transplant recipients. However,
we have shown that infections/inflammation can break transplantation tolerance. Understanding the molecular
mechanisms induced in alloreactive T cells when tolerance is successful, identifying those that are…
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