grant
Addressing Thyroid Cancer Overdiagnosis: AI-Driven Identification, Characterization, and Outcomes of Incidental Thyroid Nodules
Organization MAYO CLINIC ROCHESTERLocation ROCHESTER, UNITED STATESPosted 13 Mar 2026Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY202621+ years oldAI AugmentedAI assistedAI based modelAI drivenAI enhancedAI integratedAI language modelsAI modelAI poweredAI systemAddressAdoptedAdultAdult HumanAlgorithmsArtificial IntelligenceArtificial Intelligence enhancedAugmented by AIAugmented by the AIAugmented with AIAugmented with the AIBankruptcyBiopsyCAT scanCT X RayCT XrayCT imagingCT scanCancer PatientCharacteristicsChestClinicClinicalComprehensionComputed TomographyComputer ReasoningDataData SetDetectionDiagnosisDiagnosticDiagnostic MethodDiagnostic ProcedureDiagnostic TechniqueEnsureEthicistsEthics ConsultantsEvaluationEvaluation MethodologyEvaluation ReportsExposure toFaceFinancial HardshipFinancial InsolvencyFloridaFrequenciesGeneral RadiologyGoalsGuidelinesHealthHealth Care CostsHealth Care SystemsHealth CostsHealth Services EvaluationHealth Services ResearchHealth systemImageIncidenceIndividualInterventionInvestigatorsKnowledgeLesionLinkMRI ScansMachine IntelligenceMachine LearningMagnetic ResonanceMagnetic Resonance Imaging ScanMalignant Thyroid Gland NeoplasmMalignant Tumor of the ThyroidMalignant Tumor of the Thyroid GlandMalignant neoplasm of thyroidMarylandMedicalMedical Care ResearchModalityModelingNamesNatural Language ProcessingNeckNoduleOperative ProceduresOperative Surgical ProceduresOutcomePETPET ScanPET imagingPETSCANPETTPapillary Thyroid CancerPapillary Thyroid Gland CancerPapillary thyroid carcinomaPathway interactionsPatient CarePatient Care DeliveryPatient outcomePatient riskPatient-Centered OutcomesPatient-Focused OutcomesPatientsPerformancePopulationPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyProcessRad.-PETRadiologyRadiology SpecialtyReportingResearch PersonnelResearchersRiskSiteSocietiesStandardizationSubgroupSurgicalSurgical InterventionsSurgical ProcedureSurgical complicationSystemTechniquesTestingThoraceThoracicThoraxThyroidThyroid CancerThyroid GlandThyroid Gland NoduleThyroid Gland Papillary CarcinomaThyroid Head and NeckThyroid NoduleTomodensitometryTransformer language modelUniversitiesValidationVariantVariationX-Ray CAT ScanX-Ray Computed TomographyX-Ray Computerized TomographyXray CAT scanXray Computed TomographyXray computerized tomographyadulthoodartificial intelligence assistedartificial intelligence augmentedartificial intelligence drivenartificial intelligence integratedartificial intelligence language modelsartificial intelligence modelartificial intelligence poweredartificial intelligence-based modelbasebasescancer carecancer diagnosiscare for patientscare of patientscaring for patientscatscancomputed axial tomographycomputer tomographycomputerized axial tomographycomputerized tomographycostdevelop therapyeconomic hardshipeconomic strainenhanced with AIenhanced with Artificial Intelligencefacesfacialfinancial adversityfinancial burdenfinancial distressfinancial insecurityfinancial instabilityfinancial strainfinancial stressfinancial worryhigh riskimage-based methodimagingimaging methodimaging modalityimprovedintervention developmentlarge language modellarge scale language modellearning algorithmmachine based learningmassive scale language modelsmortalitynamenamednamingnatural language understandingnon-contrast CTnoncontrast CTnoncontrast computed tomographynovelpathwaypatient oriented outcomespositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographyresilienceresilientservices researchsurgerysurgery complicationtherapy developmenttooltreatment developmentultrasoundunnecessary treatmentvalidations
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PROJECT SUMMARY/ABSTRACT
The overdiagnosis of thyroid cancer, primarily driven by the detection of small, asymptomatic papillary thyroid
cancers, imposes significant medical and financial burdens. Despite low mortality, patients often undergo
unnecessary treatments, facing risks such as surgical complications and financial distress. By 2030, the…
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