grant
Adaptive Randomization of Aerobic Exercise During Chemotherapy in Colon Cancer
Organization ADVENTHEALTH ORLANDOLocation ORLANDO, UNITED STATESPosted 3 Jun 2022Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AdherenceAdverse ExperienceAdverse eventAerobic ActivityAerobic ExerciseAerobic TrainingAerobic fitnessBehavioralBiological MarkersBlood NeutrophilBlood Polymorphonuclear NeutrophilBody CompositionBody TissuesBody fatBostonCTCAECalibrationCancer SurvivorCancersCaringCellular Immune FunctionCertificationCessation of lifeChemotaxisClinicalClinical Practice GuidelineColon CancerColon CarcinomaCommon Terminology Criteria for Adverse EventsCommon Toxicity CriteriaComplexCounselingDEXADXADataDeathDoseDose LimitingDrug KineticsDrug or chemical Tissue DistributionDrugsDual-Energy X-Ray AbsorptiometryDual-Energy Xray AbsorptiometryElastasesExerciseFatsFatty acid glycerol estersGeographic AreaGeographic LocationsGeographic RegionGeographical LocationGuidelinesHemi-MyeloperoxidaseHistone H3HomeImmune RegulatorsImmune systemImmunomodulatorsImpairmentIncidenceInterventionLeannessMalignant NeoplasmsMalignant TumorMarrow NeutrophilMeasuresMedicationMuscleMuscle TissueMyeloperoxidaseNeutropeniaNeutrophilic GranulocyteNeutrophilic LeukocyteObesityOxidative BurstPNS DiseasesParticipantPatient Outcomes AssessmentsPatient Reported MeasuresPatient Reported OutcomesPatientsPeripheral Nerve DiseasesPeripheral Nervous System DiseasesPeripheral Nervous System DisordersPeripheral NeuropathyPeroxidasesPharmaceutical PreparationsPharmacokineticsPhenotypePhonePhysiologicPhysiologicalPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPrescribed exerciseProbabilityRaceRacesRandomizedRecommendationRecurrent diseaseRelapsed DiseaseReportingResearch DesignRespiratory BurstRiskSeveritiesStretchingStudy TypeSupportive TherapySupportive careSymptomsTechniquesTelephoneThinnessTimeTissue DistributionTissuesToxic effectToxicitiesToxicity due to chemotherapyTranslatingVariantVariationadiposityattentional controlbehavior changebio-markersbiologic markerbiomarkercancer carecancer in the colonchemotherapychemotherapy toxicityclinical practice and guidelinescorpulencedrug/agentevidence baseexercise adherenceexercise physiologistexercise prescriptionexercise trainingexperiencegastrointestinalgeographic siteheart rate monitorhomesimmune functionimmune modulatorsimmunomodulatory moleculesimmunoregulatorimmunoregulatory moleculesimprovedleukocyte oxidative burstmalignancymuscle bulkmuscle formmuscle massmuscularneoplasm/cancerneutrophilnovelpatient centeredpatient orientedpreservationprimary end pointprimary endpointracialracial backgroundracial originrandomisationrandomizationrandomly assignedrecruitresponsesarcopenic obesitysecondary end pointsecondary endpointsocio-economicsocio-economicallysocioeconomicallysocioeconomicsstudy designsynergismtreadmillvideo callvideo callingvideo chatvideo phone call
Description preview
PROJECT SUMMARY/ABSTRACT
Patients with colon cancer who require chemotherapy dose reductions and treatment delays are twice as likely
to experience disease recurrence and death than patients who complete their full chemotherapy dose on time.
Up to 60% of patients develop toxicities of sufficient severity to require chemotherapy dose reductions or…
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