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Adaptations in Corticostriatal Networks in Alcohol Dependence Related Goal-Directed and Habitual Drinking

Organization MEDICAL UNIVERSITY OF SOUTH CAROLINALocation CHARLESTON, UNITED STATESPosted 1 Dec 1996Deadline 31 Dec 2025 ⚠️
NIHUS FederalResearch GrantFY2025Absolute ethanolAcuteAlcohol Chemical ClassAlcohol dependenceAlcoholicAlcoholsAnimal ModelAnimal Models and Related StudiesAnimalsBehaviorBehavior ControlBehavioralBehavioral ManipulationBoozerBrainBrain Nervous SystemBrain regionCalciumCell BodyCellsChronicClinical ResearchClinical StudyConsumptionCorpus StriatumCorpus striatum structureD1 receptorD2 receptorDRD2 ReceptorDataDependenceDependent drinkerDevelopmentDopamineDopamine D1 ReceptorDopamine D2 ReceptorDopamine ReceptorDrugsETOHElectrodesElectrophysiologyElectrophysiology (science)ElementsEncephalonEthanolEthyl AlcoholFiberGeneticGoalsGrain AlcoholHabitsHumanHydroxytyramineImpairmentIndividualKnowledgeLaboratoriesMedialMediatingMedicationMethylcarbinolMiceMice MammalsModern ManMurineMusNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeurobiologyNeurocyteNeuronal TransmissionNeuronsNeurophysiology / ElectrophysiologyOutcomePharmaceutical PreparationsPhotometryPlayPopulationPrefrontal CortexProcessPublishingR-Series Research ProjectsR01 MechanismR01 ProgramReportingResearchResearch GrantsResearch Project GrantsResearch ProjectsRewardsRoleSaccharoseSiteSliceStriate BodyStriatumSucroseTestingVisualaddictionaddictive disorderalcohol addictionalcohol dependencyalcohol dependentalcohol exposedalcohol exposurealcohol related researchalcohol researchalcohol seekingalcohol seeking behavioralcohol use disorderaxon signalingaxon-glial signalingaxonal signalingbehavioral controlbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical parametersbiophysical propertiescell typecompare to controlcomparison controldevelopmentaldrinkingdrinking behaviordrug seeking behaviordrug/agenteffective therapyeffective treatmentelectrophysiologicalethanol exposedethanol exposureethanol researchethanol seekingethanol use disorderethanol-seeking behaviorexperimentexperimental researchexperimental studyexperimentsexposed to alcoholexposed to ethanolexposure to alcoholexposure to ethanolflexibilityflexibleglia signalingglial signalinghuman imagingimaging studyin vivomalemodel of animalmouse modelmurine modelnerve signalingneural circuitneural circuitryneural networkneural signalingneurobiologicalneurocircuitryneuronalneuronal signalingneurotransmissionnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpatch clamppre-clinical researchpreclinical researchproblem drinkerresponsesocial rolestriatalsynaptic circuitsynaptic circuitrytreatment centerβ™‚

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PROJECT SUMMARY
The development of alcohol addiction is increasingly viewed as involving transition from controlled and

regulated consumption to uncontrolled drinking characterized as compulsive and habitual. Recent studies in

human alcoholics and animal models have suggested that chronic alcohol exposure may induce

neurobiological changes in…

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