grant
ADAM10 as a molecular specifier of sepsis
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Aug 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025(TNF)-α7B4 Antigen7B4 proteinAnatomic SitesAnatomic structuresAnatomyAnimal Disease ModelsAntibiotic AgentsAntibiotic DrugsAntibioticsAutoregulationBasic ResearchBasic ScienceBindingBiologicalBiologyBlood PlateletsBlood VesselsBody TissuesC albicansC. albicansC.albicansCD144 AntigenCD44CD44 geneCLP modelCLP mouse modelCachectinCandida albicansCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCause of DeathCecal ligation perforationCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCell membraneCellular FunctionCellular PhysiologyCellular ProcessCessation of lifeClinicalClinical TreatmentCommunicable DiseasesComplementComplement ProteinsComplexCytoplasmic MembraneD pneumoniaeD. pneumoniaeDT-RDTR geneDataDeathDependenceDevelopmentDiphtheria Toxin Receptor (Heparin-Binding EGF-Like Growth Factor) GeneDiphtheria Toxin Receptor GeneDiphtheria Toxin Sensitivity GeneDiplococcus pneumoniaeDiseaseDisintegrinsDisorderDysfunctionElementsEndothelial CellsEndotheliumEnsureEnvironmentEventFacultyFunctional disorderFundingFutureGenetic PolymorphismGoalsHB-EGFHBEGFHEGFLHeparin-Binding EGF-Like Growth Factor GeneHistoryHomeostasisHospital CostsHospitalization costHumanIV FluidImmune responseImmunologyIn VitroInfectionInfectious DiseasesInfectious DisorderInflammatoryInjuryIntracellular Communication and SignalingIntravenous FluidInvadedInvestigatorsK-AwardsK-Series Research Career ProgramsKO miceKnock-outKnock-out MiceKnockoutKnockout MiceKnowledgeLaboratory StudyLearningLifeLipopolysaccharidesMDU3Macrophage-Derived TNFMagicMarrow plateletMediatingMediatorMentorsMetallopeptidasesMetalloproteasesMetalloproteinasesMiceMice MammalsMiscellaneous AntibioticModelingModern ManMolecularMolecular InteractionMonocyte-Derived TNFMurineMusNatureNull MouseOrganP aeruginosaP. aeruginosaPathogenesisPathway interactionsPgp1PhysiciansPhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyPlasma MembranePlateletsPlayPneumococcusPopulationProteomicsPseudomonas aeruginosaPseudomonas pyocyaneaPublic HealthReceptor ProteinRecording of previous eventsResearchResearch Career ProgramResearch PersonnelResearchersResolutionRiskRoleS agalactiaeS aureusS pneumoniaeS. agalactiaeS. aureusS. pneumoniaeScientistSepsisSeptic ShockSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStaph aureusStaphylococcus aureusStreptococcus Group BStreptococcus agalactiaeStreptococcus pneumoniaeSubcellular ProcessSupportive TherapySupportive careSyndromeSystemic infectionTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTherapeuticThrombocytesThrombosisThrombusTissuesToxinTrainingTranslatingTranslational ResearchTranslational ScienceTreatment FailureTumor Necrosis FactorTumor Necrosis Factor-alphaUpregulationVE-CadherinVEGFVEGFsVascular Endothelial CadherinVascular Endothelial Cadherin 1Vascular Endothelial Growth FactorsVascular EndotheliumVirulenceantisepsis treatmentbacteria pathogenbacterial pathogenbiologicbiological signal transductioncadherin 5careercareer developmentcecal ligation and perforationcecal ligation and puncturececal ligation puncturececum ligation and puncturececum ligation punctureclinical interventionclinical therapycomplementationdeath due to sepsisdeath related to sepsisdesigndesigningdevelopmentalefficacious therapyefficacious treatmentendomucinendothelial-specific sialomucinhistorieshost responsehuman pathogenimaging in vivoimmune system responseimmunoresponsein vivoin vivo imaginginjuriesinjury to organsinsightmembermortalitymortality associated with sepsismortality in sepsismouse modelmultiorgan damagemurine modelnew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnotchnotch proteinnotch receptorsnovelnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapyorgan injurypathogenpathogenic bacteriapathophysiologypathwayplasmalemmapolymorphismpre-clinical researchpreclinical researchpreventpreventingpromoterpromotorreceptorresolutionssensorsepsis associated deathsepsis associated mortalitysepsis caresepsis caused deathssepsis deathsepsis induced deathsepsis induced mortalitysepsis interventionssepsis lethalitysepsis managementsepsis mortalitysepsis related deathssepsis related mortalitysepsis therapeuticssepsis therapysepsis treatmentsepticseptic deathseptic mortalityseptic therapyseptic treatmentsevere sepsisseverely septicskillssocial roletherapeutic agent developmenttherapeutic developmenttherapy failurethrombotic diseasethrombotic disordertranslation researchtranslational investigationtreat sepsistrial regimentrial treatmentvascularα-Toxin
Description preview
PROJECT ABSTRACT
This proposed career development award will provide Dr. Danielle Alfano, MD with targeted mentored training to
ensure she develops into an independent researcher utilizing both experimental approaches, mouse models,
and “omics”, to probe how specific pathogens harness ADAM10 leading to the dysregulated endothelial and host…
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