grant
Acute neural injury and posttraumatic epilepsy
Organization UNIVERSITY OF CALIFORNIA RIVERSIDELocation RIVERSIDE, UNITED STATESPosted 14 Jun 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2026AcuteAmmon HornAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesArmed Forces PersonnelAstrocytesAstrocytusAstrogliaBiological MarkersBody TissuesBrainBrain Nervous SystemBrain TraumaCell BodyCell DeathCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessChronicClinicalCornu AmmonisCraniocerebral InjuriesCraniocerebral TraumaDataDevelopmentDiseaseDisorderDistantDysfunctionEEGElectrodesElectroencephalogramElectroencephalographyElectrophysiologyElectrophysiology (science)EncephalonEpilepsyEpileptic SeizuresEpilepticsEpileptogenesisExhibitsFoundationsFunctional disorderGliaGlial CellsGlutamatesGoalsHead InjuriesHead TraumaHippocampusImmunoblottingImpairmentInjuryKnowledgeKolliker's reticulumL-GlutamateMiceMice MammalsMilitaryMilitary PersonnelMissionModelingMolecularMonitorMurineMusNational Institutes of HealthNerve CellsNerve UnitNeural CellNeurocyteNeurogliaNeuroglial CellsNeuronsNeurophysiology / ElectrophysiologyNon-neuronal cellNonneuronal cellPathogenesisPathologyPermeabilityPhysiologicPhysiologicalPhysiopathologyPopulationPost-Traumatic EpilepsyPost-Traumatic Seizure DisorderPredispositionProcessPublic HealthPyramidal CellsReproducibilityResearchSeizure DisorderSeizuresSiteSliceSubcellular ProcessSurfaceSusceptibilitySynapsesSynapticTechniquesTestingTimeTissuesTraumaTraumatic Brain InjuryTraumatic EpilepsyUnited States National Institutes of HealthWestern BlottingWestern Immunoblottingastrocytic gliabio-markersbiologic markerbiomarkercell typecellular targetingcontrolled cortical impactdevelopmentalelectrophysiologicalepilepsiaepileptogenicexcitotoxicexcitotoxicityexperimentexperimental researchexperimental studyexperimentsglutamatergichippocampalinjuredinjuriesmilitary populationmodel of animalmolecular targeted therapeuticsmolecular targeted therapiesmolecular targeted treatmentmulti-electrode arraysmulti-modalitymultielectrode arraysmultimodalitynecrocytosisnerve cementnerve injuryneural injuryneuronalnovelpathophysiologypredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerprotein blottingsynapsetargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttraumatic brain damage
Description preview
PROJECT SUMMARY
Posttraumatic epilepsy (PTE) refers to chronic unprovoked seizures following traumatic brain injury (TBI),
and is a major clinical problem in both the military and civilian populations. Despite the importance of PTE,
the locus of where PTE develops relative to the site of head injury and thus the anatomy of development of
PTE in…
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