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Acupuncture for Chemothrapy-induced Peripheral Neuropathy Treatment (ACT) Trial
Organization DANA-FARBER CANCER INSTLocation BOSTON, UNITED STATESPosted 1 Dec 2023Deadline 30 Nov 2025 ⚠️
NIHUS FederalResearch GrantFY20253-arm randomized trial3-arm trialASCOActive Follow-upAcupuncture TherapyAcupuncture procedureAffectAmerican Society of Clinical OncologyAnalgesia TestsAnalgesic AgentsAnalgesic DrugsAnalgesic PreparationAnalgesicsAnodynesAntinociceptive AgentsAntinociceptive DrugsBrief Pain InventoryCancer CenterCancer PatientCancer SurvivorCephalalgiaCephalgiaCephalodyniaChemotherapy-induced peripheral neuropathyChinese Traditional MedicineChinese medicineChung I HsuehClinicalClinical Trials DesignComplicationCranial PainDataDisablingDouble-Blind MethodDouble-Blind StudyDouble-BlindedDouble-Masked MethodDouble-Masked StudyDrugsEffectivenessElectroacupunctureFatigueFiberGoalsHead PainHeadacheHourImpairmentInterventionLack of EnergyLong-term Follow-upLoss of SensationMeasurementMeasuresMedicationMethodsNauseaNeurobiologyNociception TestsNon-pharmacologic TherapyNonpharmacologic InterventionNonpharmacologic TherapyNonpharmacologic approachNonpharmacologic treatmentNumbnessNumeric Rating ScaleNumerical ScalePNS DiseasesPainPain AssessmentPain MeasurementPain ThresholdPain Tolerance LevelPain measurePainfulParticipantPatient CarePatient Care DeliveryPatient PreferencesPatientsPeripheral Nerve DiseasesPeripheral Nervous System DiseasesPeripheral Nervous System DisordersPeripheral NeuropathyPharmaceutical PreparationsPhasePilot ProjectsPlacebosPrediction of Response to TherapyQOLQOL improvementQuality of lifeRandomizedRandomized, Controlled TrialsRecommendationRecoveryResearchRoleSample SizeScientistSensorySeveritiesSham TreatmentSolid NeoplasmSolid TumorSymptomsTactileTechniquesTestingTreatment-related toxicityUnited StatesZhong Yi Xueactive followupacupunctureafferent nervearmblindcare as usualcare for patientscare of patientscare providerscaring for patientschemotherapychronic MSK painchronic musculoskeletal painconditioned pain modulationdetermine efficacydrug/agentduloxetineeffective therapyeffective treatmentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacyexperiencefollow upfollow-upfollowed upfollowupfunctional improvementhead acheimprove functionimprovedimproved functional outcomesimprovements in QOLimprovements in quality of lifelong-term followupminimally invasivemultidisciplinaryneurobiologicalneuropathic painneurotoxicnew approachesnon-drug therapynon-drug treatmentnondrug therapynondrug treatmentnovel approachesnovel strategiesnovel strategyoutcome predictionpain assaypain killerpain medicationpain reductionpain relieverpain tolerancepainful neuropathypainkillerpersonalized chemotherapypharmacologicpilot studyplacebo controlled studyprecision chemotherapypredict responsivenesspredict therapeutic responsepredict therapy responsepredicting responsepressureprimary outcomequality of life improvementrandomisationrandomizationrandomized control trialrandomized placebo-controlled clinical trialrandomly assignedreduce painresponse to therapyresponse to treatmentsensory nervesham therapyside effectsocial rolestandard of caretherapeutic responsetherapeutic toxicitytherapy associated toxicitytherapy predictiontherapy related toxicitytherapy responsetherapy toxicitythree-arm randomized trialthree-arm trialtreatment as usualtreatment effecttreatment predictiontreatment responsetreatment response predictiontreatment responsivenesstreatment toxicitytreatment-associated toxicityusual carevibration
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Project Summary
One of the most harmful side effects of chemotherapy is chemotherapy-induced peripheral
neuropathy (CIPN), a common, painful, and disabling side effect of many chemotherapy agents
for which there is no effective treatment. Our pilot phase IIB three-arm trial showed that
acupuncture treatment is associated with reduced CIPN pain and…
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